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Int. J. Mol. Sci. 2014, 15(7), 12791-12806; doi:10.3390/ijms150712791

Antibacterial Effect of Dental Adhesive Containing Dimethylaminododecyl Methacrylate on the Development of Streptococcus mutans Biofilm

1
State Key Laboratory of Oral Diseases, Sichuan University, Wuhou District, Chengdu 610041, China
2
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
3
Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 9 June 2014 / Revised: 27 June 2014 / Accepted: 2 July 2014 / Published: 18 July 2014
(This article belongs to the Special Issue Antimicrobial Polymers)
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Abstract

Antibacterial bonding agents and composites containing dimethylaminododecyl methacrylate (DMADDM) have been recently developed. The objectives of this study were to investigate the antibacterial effect of novel adhesives containing different mass fractions of DMADDM on Streptococcus mutans (S. mutans) biofilm at different developmental stages. Different mass fractions of DMADDM were incorporated into adhesives and S. mutans biofilm at different developmetal stages were analyzed by MTT assays, lactic acid measurement, confocal laser scanning microscopy and scanning electron microscopy observations. Exopolysaccharides (EPS) staining was used to analyze the inhibitory effect of DMADDM on the biofilm extracellular matrix. Dentin microtensile strengths were also measured. Cured adhesives containing DMADDM could greatly reduce metabolic activity and lactic acid production during the development of S. mutans biofilms (p < 0.05). In earlier stages of biofilm development, there were no significant differences of inhibitory effects between the 2.5% DMADDM and 5% DMADDM group. However, after 72 h, the anti-biofilm effects of adhesives containing 5% DMADDM were significantly stronger than any other group. Incorporation of DMADDM into adhesive did not adversely affect dentin bond strength. In conclusion, adhesives containing DMADDM inhibited the growth, lactic acid production and EPS metabolism of S. mutans biofilm at different stages, with no adverse effect on its dentin adhesive bond strength. The bonding agents have the potential to control dental biofilms and combat tooth decay, and DMADDM is promising for use in a wide range of dental adhesive systems and restoratives. View Full-Text
Keywords: antibacterial adhesive; DMADDM; S. mutans biofilm; microtensile antibacterial adhesive; DMADDM; S. mutans biofilm; microtensile
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MDPI and ACS Style

Wang, S.; Zhang, K.; Zhou, X.; Xu, N.; Xu, H.H.K.; Weir, M.D.; Ge, Y.; Wang, S.; Li, M.; Li, Y.; Xu, X.; Cheng, L. Antibacterial Effect of Dental Adhesive Containing Dimethylaminododecyl Methacrylate on the Development of Streptococcus mutans Biofilm. Int. J. Mol. Sci. 2014, 15, 12791-12806.

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