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Int. J. Mol. Sci. 2014, 15(7), 11957-11972; doi:10.3390/ijms150711957

Catalpol Ameliorates Sodium Taurocholate-Induced Acute Pancreatitis in Rats via Inhibiting Activation of Nuclear Factor Kappa B

1
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Zhabei District, Shanghai 200072, China
2
Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiaotong University School of Medicine, 100 Haining Road, Hongkou District, Shanghai 200080, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 11 May 2014 / Revised: 3 June 2014 / Accepted: 20 June 2014 / Published: 4 July 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Catalpol, an iridoid glucoside extracted from the traditional Chinese herbal medicine, Rehmannia glutinosa, is reported to exert neuroprotective, anti-inflammatory, anti-tumor and anti-apoptotic effects. The main aim of the present study was to investigate whether catalpol ameliorates experimental acute pancreatitis (AP) induced by sodium taurocholate (STC). AP was induced in rats via retrograde injection of 4% STC (0.1 mL/100 g) into the biliopancreatic duct. Rats were pre-treated with saline or catalpol (50 mg/kg) 2 h before STC injection. At 12, 24 and 48 h after injection, the severity of AP was evaluated using biochemical and morphological analyses. Pretreatment with catalpol led to a significant reduction in serum amylase and lipase activities, pancreatic histological damage, myeloperoxidase (MPO) activity, interleukin (IL)-1β, IL-6 and TNF-α levels, and activation of nuclear factor kappa B (NF-κB). Moreover, administration of catalpol increased the viability of pancreatic acinar cells and inhibited NF-κB expression in vitro. Our results collectively support the potential of catalpol as a highly effective therapeutic agent for treatment of AP. View Full-Text
Keywords: acute pancreatitis; catalpol; inflammatory cytokines; NF-kB acute pancreatitis; catalpol; inflammatory cytokines; NF-kB
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MDPI and ACS Style

Xiao, W.Q.; Yin, G.J.; Fan, Y.T.; Qiu, L.; Cang, X.F.; Yu, G.; Hu, Y.L.; Xing, M.; Wu, D.Q.; Wang, X.P.; Hu, G.Y.; Wan, R. Catalpol Ameliorates Sodium Taurocholate-Induced Acute Pancreatitis in Rats via Inhibiting Activation of Nuclear Factor Kappa B. Int. J. Mol. Sci. 2014, 15, 11957-11972.

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