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Int. J. Mol. Sci. 2014, 15(7), 11973-11983; doi:10.3390/ijms150711973

miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1

1
Department of Thoracic-Cardio Surgery, the First Affiliated Hospital of PLA General Hospital, Beijing 100048, China
2
Department of Medical Oncology, the General Hospital of People's Liberation Army, Beijing 100853, China
3
Department of Thoracic Surgery, the General Hospital of People's Liberation Army, Beijing 100853, China
4
Key Laboratory of Cancer Prevention and Therapy of Tianjin, Department of Senior Ward, Tianjin Medical University Cancer Institute and Hospital, Huanhu Xilu, Hexi District, Tianjin 300060, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 7 May 2014 / Revised: 9 June 2014 / Accepted: 16 June 2014 / Published: 7 July 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

MicroRNAs (miRNAs) have essential roles in carcinogenesis and tumor progression. Here, we investigated the roles and mechanisms of miR-143 in non-small cell lung cancer (NSCLC). miR-143 was significantly decreased in NSCLC tissues and cell lines. Overexpression of miR-143 suppressed NSCLC cell proliferation, induced apoptosis, and inhibited migration and invasion in vitro. Integrated analysis identified LIM domain kinase 1 (Limk1) as a direct and functional target of miR-143. Overexpression of Limk1 attenuated the tumor suppressive effects of miR-143 in NSCLC cells. Moreover, miR-143 was inversely correlated with Limk1 expression in NSCLC tissues. Together, our results highlight the significance of miR-143 and Limk1 in the development and progression of NSCLC. View Full-Text
Keywords: miR-143; NSCLC; Limk1; proliferation; migration; invasion miR-143; NSCLC; Limk1; proliferation; migration; invasion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Xia, H.; Sun, S.; Wang, B.; Wang, T.; Liang, C.; Li, G.; Huang, C.; Qi, D.; Chu, X. miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1. Int. J. Mol. Sci. 2014, 15, 11973-11983.

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