miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1
AbstractMicroRNAs (miRNAs) have essential roles in carcinogenesis and tumor progression. Here, we investigated the roles and mechanisms of miR-143 in non-small cell lung cancer (NSCLC). miR-143 was significantly decreased in NSCLC tissues and cell lines. Overexpression of miR-143 suppressed NSCLC cell proliferation, induced apoptosis, and inhibited migration and invasion in vitro. Integrated analysis identified LIM domain kinase 1 (Limk1) as a direct and functional target of miR-143. Overexpression of Limk1 attenuated the tumor suppressive effects of miR-143 in NSCLC cells. Moreover, miR-143 was inversely correlated with Limk1 expression in NSCLC tissues. Together, our results highlight the significance of miR-143 and Limk1 in the development and progression of NSCLC. View Full-Text
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Xia, H.; Sun, S.; Wang, B.; Wang, T.; Liang, C.; Li, G.; Huang, C.; Qi, D.; Chu, X. miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1. Int. J. Mol. Sci. 2014, 15, 11973-11983.
Xia H, Sun S, Wang B, Wang T, Liang C, Li G, Huang C, Qi D, Chu X. miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1. International Journal of Molecular Sciences. 2014; 15(7):11973-11983.Chicago/Turabian Style
Xia, Hui; Sun, Shengjie; Wang, Bo; Wang, Tao; Liang, Chaoyang; Li, Guo; Huang, Chongbiao; Qi, Daliang; Chu, Xiangyang. 2014. "miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1." Int. J. Mol. Sci. 15, no. 7: 11973-11983.