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Geminal Brønsted Acid Ionic Liquids as Catalysts for the Mannich Reaction in Water
AbstractQuaternary ammonium geminal Brønsted acid ionic liquids (GBAILs) based on zwitterionic 1,2-bis[N-methyl-N-(3-sulfopropyl)-alkylammonium]ethane (where the carbon number of the alkyl chain is 4, 8, 10, 12, 14, 16, or 18) and p-toluenesulfonic acid monohydrate were synthesized. The catalytic ionic liquids were applied in three-component Mannich reactions with an aldehyde, ketone, and amine at 25 °C in water. The effects of the type and amount of catalyst and reaction time as well as the scope of the reaction were investigated. Results showed that GBAIL-C14 has excellent catalytic activity and fair reusability. The catalytic procedure was simple, and the catalyst could be recycled seven times via a simple separation process without noticeable decreases in catalytic activity.
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He, L.; Qin, S.; Chang, T.; Sun, Y.; Zhao, J. Geminal Brønsted Acid Ionic Liquids as Catalysts for the Mannich Reaction in Water. Int. J. Mol. Sci. 2014, 15, 8656-8666.View more citation formats
He L, Qin S, Chang T, Sun Y, Zhao J. Geminal Brønsted Acid Ionic Liquids as Catalysts for the Mannich Reaction in Water. International Journal of Molecular Sciences. 2014; 15(5):8656-8666.Chicago/Turabian Style
He, Leqin; Qin, Shenjun; Chang, Tao; Sun, Yuzhuang; Zhao, Jiquan. 2014. "Geminal Brønsted Acid Ionic Liquids as Catalysts for the Mannich Reaction in Water." Int. J. Mol. Sci. 15, no. 5: 8656-8666.