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Int. J. Mol. Sci. 2014, 15(5), 8352-8359; doi:10.3390/ijms15058352

Effect of Long-Term Dietary Arginyl-Fructose (AF) on Hyperglycemia and HbA1c in Diabetic db/db Mice

1
Thrombosis and Vascular Biochemistry Lab., Department of Applied Science, CHA University, Gyeonggi-do 463-836, Korea
2
Department of Food and Nutrition, Hannam University, Daejeon 305-811, Korea
3
Department of Nutrition and Food Science, University of Rhode Island, Kingston, RI 02881, USA
4
Department of Nutrition, University of Massachusetts, Amherst, MA 01003, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 12 March 2014 / Revised: 29 April 2014 / Accepted: 3 May 2014 / Published: 12 May 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

We have previously reported that Amadori compounds exert anti-diabetic effects by lowering sucrose-induced hyperglycemia in normal Sprague-Dawley rats. In the present study we extended our recent findings to evaluate whether α-glucosidase inhibitor arginyl-fructose (AF) lowers blood glucose level in diabetic db/db mice, a genetic model for type 2 diabetes. The db/db mice were randomly assigned to high-carbohydrate diets (66.1% corn starch) with and without AF (4% in the diet) for 6 weeks. Changes in body weight, blood glucose level, and food intake were measured daily for 42 days. Dietary supplementation of AF resulted in a significant decrease of blood glucose level (p < 0.001) and body weight (p < 0.001). The level of HbA1c, a better indicator of plasma glucose concentration over prolonged periods of time, was also significantly decreased for 6-week period (p < 0.001). Dietary treatment of acarbose® (0.04% in diet), a positive control, also significantly alleviated the level of blood glucose, HbA1c, and body weight. These results indicate that AF Maillard reaction product improves postprandial hyperglycemia by suppressing glucose absorption as well as decreasing HbA1c level. View Full-Text
Keywords: type 2 diabetes; pre-diabetes; blood glucose; α-glucosidase inhibition; arginyl-fructose (AF) type 2 diabetes; pre-diabetes; blood glucose; α-glucosidase inhibition; arginyl-fructose (AF)
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lee, K.-H.; Ha, K.-S.; Jo, S.-H.; Lee, C.M.; Kim, Y.-C.; Chung, K.-H.; Kwon, Y.-I. Effect of Long-Term Dietary Arginyl-Fructose (AF) on Hyperglycemia and HbA1c in Diabetic db/db Mice. Int. J. Mol. Sci. 2014, 15, 8352-8359.

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