Next Article in Journal
Effect of Long-Term Dietary Arginyl-Fructose (AF) on Hyperglycemia and HbA1c in Diabetic db/db Mice
Next Article in Special Issue
Cytotoxic Autophagy in Cancer Therapy
Previous Article in Journal
Silencing of the CaCP Gene Delays Salt- and Osmotic-Induced Leaf Senescence in Capsicum annuum L.
Previous Article in Special Issue
The Role of Survivin in Podocyte Injury Induced by Puromycin Aminonucleoside
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(5), 8335-8351; doi:10.3390/ijms15058335

Apoptotic Death of Cancer Stem Cells for Cancer Therapy

Division of Stem Cell Regulation and Application, College of Medicine, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
Department of Medical Microbiology, Immunology & Cell Biology, Simmons Cancer Institute, Southern Illinois University School of Medicine, 913 N, Rutledge Street, Springfield, IL 62702, USA
Authors to whom correspondence should be addressed.
Received: 24 February 2014 / Revised: 18 April 2014 / Accepted: 18 April 2014 / Published: 12 May 2014
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
View Full-Text   |   Download PDF [352 KB, uploaded 19 June 2014]   |  


Cancer stem cells (CSCs) play crucial roles in tumor progression, chemo- and radiotherapy resistance, and recurrence. Recent studies on CSCs have advanced understanding of molecular oncology and development of novel therapeutic strategies. This review article updates the hypothesis and paradigm of CSCs with a focus on major signaling pathways and effectors that regulate CSC apoptosis. Selective CSC apoptotic inducers are introduced and their therapeutic potentials are discussed. These include synthetic and natural compounds, antibodies and recombinant proteins, and oligonucleotides. View Full-Text
Keywords: cancer stem cells; side population; apoptosis; apoptotic inducers; apoptotic death pathways; and cancer therapy cancer stem cells; side population; apoptosis; apoptotic inducers; apoptotic death pathways; and cancer therapy

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

He, Y.-C.; Zhou, F.-L.; Shen, Y.; Liao, D.-F.; Cao, D. Apoptotic Death of Cancer Stem Cells for Cancer Therapy. Int. J. Mol. Sci. 2014, 15, 8335-8351.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top