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Int. J. Mol. Sci. 2014, 15(5), 8091-8105; doi:10.3390/ijms15058091

Synthesis and Characterization of Novel Purpurinimides as Photosensitizers for Photodynamic Therapy

1
College of Medicine, Hubei Polytechnic University, Huangshi 435003, China
2
Photodynamic Therapy (PDT) Research Institute, School of Nano System Engineering, Inje University, Gimhae 621-749, Korea
3
College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China
*
Authors to whom correspondence should be addressed.
Received: 5 January 2014 / Revised: 25 April 2014 / Accepted: 28 April 2014 / Published: 8 May 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

A series of novel purpurinimides with long wavelength absorption were designed and synthesized to develop novel and potential photosensitizers. These compounds were investigated through reduction, oxidation, rearrangement reaction and amidation reactions of methyl pheophorbide a. They demonstrated a considerable bathochromic shift of the major absorption band in the red region of the optical spectrum (695–704 nm). Newly synthesized purpurinimides were screened for their antitumor activities, and showed higher photodynamic efficiency against A549 cell lines as compared to purpurin-18 methyl ester. The results revealed the novel purpurinimides could be potential photosensitizers. View Full-Text
Keywords: purpurinimide; methyl pheophorbide a; photosensitizer; photodynamic therapy; singlet oxygen photogeneration; hydrophobicity parameter purpurinimide; methyl pheophorbide a; photosensitizer; photodynamic therapy; singlet oxygen photogeneration; hydrophobicity parameter
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MDPI and ACS Style

Cui, B.C.; Yoon, I.; Li, J.Z.; Lee, W.K.; Shim, Y.K. Synthesis and Characterization of Novel Purpurinimides as Photosensitizers for Photodynamic Therapy. Int. J. Mol. Sci. 2014, 15, 8091-8105.

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