Int. J. Mol. Sci. 2014, 15(4), 6161-6168; doi:10.3390/ijms15046161
Article

Synthesis of Cellulose-2,3-bis(3,5-dimethylphenylcarbamate) in an Ionic Liquid and Its Chiral Separation Efficiency as Stationary Phase

Received: 11 February 2014; in revised form: 26 March 2014 / Accepted: 31 March 2014 / Published: 11 April 2014
(This article belongs to the Special Issue Ionic Liquids 2014 & Selected Papers from ILMAT 2013)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A chiral selector of cellulose-2,3-bis(3,5-dimethylphenylcarbamate) (CBDMPC) was synthesized by reacting 3,5-dimethylphenyl isocyanate with microcrystalline cellulose dissolved in an ionic liquid of 1-allyl-3-methyl-imidazolium chloride (AMIMCl). The obtained chiral selector was effectively characterized by infrared spectroscopy, elemental analysis and 1H NMR. The selector was reacted with 3-aminopropylsilanized silica gel and the CBDMPC bonded chiral stationary phase (CSP) was obtained. Chromatographic evaluation of the prepared CSPs was conducted by high performance liquid chromatographic (HPLC) and baseline separation of three typical fungicides including hexaconazole, metalaxyl and myclobutanil was achieved using n-hexane/isopropanol as the mobile phase with a flow rate 1.0 mL/min. Experimental results also showed that AMIMCl could be recycled easily and reused in the preparation of CSPs as an effective reaction media.
Keywords: 1-allyl-3-methyl-imidazolium chloride; synthesis; Cellulose-2,3-bis(3,5-dimethylphenylcarbamate); high performance liquid chromatography; chiral stationary phase; enantioseparation
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MDPI and ACS Style

Liu, R.; Zhang, Y.; Bai, L.; Huang, M.; Chen, J.; Zhang, Y. Synthesis of Cellulose-2,3-bis(3,5-dimethylphenylcarbamate) in an Ionic Liquid and Its Chiral Separation Efficiency as Stationary Phase. Int. J. Mol. Sci. 2014, 15, 6161-6168.

AMA Style

Liu R, Zhang Y, Bai L, Huang M, Chen J, Zhang Y. Synthesis of Cellulose-2,3-bis(3,5-dimethylphenylcarbamate) in an Ionic Liquid and Its Chiral Separation Efficiency as Stationary Phase. International Journal of Molecular Sciences. 2014; 15(4):6161-6168.

Chicago/Turabian Style

Liu, Runqiang; Zhang, Yijun; Bai, Lianyang; Huang, Mingxian; Chen, Jun; Zhang, Yuping. 2014. "Synthesis of Cellulose-2,3-bis(3,5-dimethylphenylcarbamate) in an Ionic Liquid and Its Chiral Separation Efficiency as Stationary Phase." Int. J. Mol. Sci. 15, no. 4: 6161-6168.

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