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Int. J. Mol. Sci. 2014, 15(3), 3373-3388; doi:10.3390/ijms15033373
Article

Development of Lipid-Shell and Polymer Core Nanoparticles with Water-Soluble Salidroside for Anti-Cancer Therapy

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Received: 17 December 2013; in revised form: 23 January 2014 / Accepted: 6 February 2014 / Published: 25 February 2014
(This article belongs to the Special Issue Bioactive Nanoparticles 2014)
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Abstract: Salidroside (Sal) is a potent antitumor drug with high water-solubility. The clinic application of Sal in cancer therapy has been significantly restricted by poor oral absorption and low tumor cell uptake. To solve this problem, lipid-shell and polymer-core nanoparticles (Sal-LPNPs) loaded with Sal were developed by a double emulsification method. The processing parameters including the polymer types, organic phase, PVA types and amount were systemically investigated. The obtained optimal Sal-LPNPs, composed of PLGA-PEG-PLGA triblock copolymers and lipids, had high entrapment efficiency (65%), submicron size (150 nm) and negatively charged surface (−23 mV). DSC analysis demonstrated the successful encapsulation of Sal into LPNPs. The core-shell structure of Sal-LPNPs was verified by TEM. Sal released slowly from the LPNPs without apparent burst release. MTT assay revealed that 4T1 and PANC-1 cancer cell lines were sensitive to Sal treatment. Sal-LPNPs had significantly higher antitumor activities than free Sal in 4T1 and PANC-1 cells. The data indicate that LPNPs are a promising Sal vehicle for anti-cancer therapy and worthy of further investigation.
Keywords: salidroside; lipid-shell and polymer-core nanoparticles (LPNPs); PLGA; antitumor salidroside; lipid-shell and polymer-core nanoparticles (LPNPs); PLGA; antitumor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fang, D.-L.; Chen, Y.; Xu, B.; Ren, K.; He, Z.-Y.; He, L.-L.; Lei, Y.; Fan, C.-M.; Song, X.-R. Development of Lipid-Shell and Polymer Core Nanoparticles with Water-Soluble Salidroside for Anti-Cancer Therapy. Int. J. Mol. Sci. 2014, 15, 3373-3388.

AMA Style

Fang D-L, Chen Y, Xu B, Ren K, He Z-Y, He L-L, Lei Y, Fan C-M, Song X-R. Development of Lipid-Shell and Polymer Core Nanoparticles with Water-Soluble Salidroside for Anti-Cancer Therapy. International Journal of Molecular Sciences. 2014; 15(3):3373-3388.

Chicago/Turabian Style

Fang, Dai-Long; Chen, Yan; Xu, Bei; Ren, Ke; He, Zhi-Yao; He, Li-Li; Lei, Yi; Fan, Chun-Mei; Song, Xiang-Rong. 2014. "Development of Lipid-Shell and Polymer Core Nanoparticles with Water-Soluble Salidroside for Anti-Cancer Therapy." Int. J. Mol. Sci. 15, no. 3: 3373-3388.


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