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Int. J. Mol. Sci. 2014, 15(3), 3671-3697; doi:10.3390/ijms15033671
Review

Nanotoxicity Overview: Nano-Threat to Susceptible Populations

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 and *
Received: 10 January 2014; in revised form: 9 February 2014 / Accepted: 13 February 2014 / Published: 28 February 2014
(This article belongs to the Special Issue Bioactive Nanoparticles 2014)
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Abstract: Due to the increasing applications of nanomaterials and nanotechnology, potential danger of nanoparticle exposure has become a critical issue. However, recent nanotoxicity studies have mainly focused on the health risks to healthy adult population. The nanotoxicity effects on susceptible populations (such as pregnant, neonate, diseased, and aged populations) have been overlooked. Due to the alterations in physiological structures and functions in susceptible populations, they often suffer more damage from the same exposure. Thus, it is urgent to understand the effects of nanoparticle exposure on these populations. In order to fill this gap, the potential effects of nanoparticles to pregnant females, neonate, diseased, and aged population, as well as the possible underlying mechanisms are reviewed in this article. Investigations show that responses from susceptible population to nanoparticle exposure are often more severe. Reduced protection mechanism, compromised immunity, and impaired self-repair ability in these susceptible populations may contribute to the aggravated toxicity effects. This review will help minimize adverse effects of nanoparticles to susceptible population in future nanotechnology applications.
Keywords: nanotoxicity; susceptible populations; health risk; aged population; disease nanotoxicity; susceptible populations; health risk; aged population; disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Li, Y.; Zhang, Y.; Yan, B. Nanotoxicity Overview: Nano-Threat to Susceptible Populations. Int. J. Mol. Sci. 2014, 15, 3671-3697.

AMA Style

Li Y, Zhang Y, Yan B. Nanotoxicity Overview: Nano-Threat to Susceptible Populations. International Journal of Molecular Sciences. 2014; 15(3):3671-3697.

Chicago/Turabian Style

Li, Yang; Zhang, Yi; Yan, Bing. 2014. "Nanotoxicity Overview: Nano-Threat to Susceptible Populations." Int. J. Mol. Sci. 15, no. 3: 3671-3697.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert