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Int. J. Mol. Sci. 2014, 15(2), 3145-3153; doi:10.3390/ijms15023145

Autophagic Cell Death and Cancer

* ,
Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
* Author to whom correspondence should be addressed.
Received: 6 January 2014 / Revised: 10 February 2014 / Accepted: 13 February 2014 / Published: 21 February 2014
(This article belongs to the collection Programmed Cell Death and Apoptosis)
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Programmed cell death (PCD) is a crucial process required for the normal development and physiology of metazoans. The three major mechanisms that induce PCD are called type I (apoptosis), type II (autophagic cell death), and type III (necrotic cell death). Dysfunctional PCD leads to diseases such as cancer and neurodegeneration. Although apoptosis is the most common form of PCD, recent studies have provided evidence that there are other forms of cell death. One of such cell death is autophagic cell death, which occurs via the activation of autophagy. The present review summarizes recent knowledge about autophagic cell death and discusses the relationship with tumorigenesis.
Keywords: programmed cell death; autophagic cell death; Atg5-independent autophagy; Beclin1; tumorigenesis; c-Jun N-terminal kinase (JNK) programmed cell death; autophagic cell death; Atg5-independent autophagy; Beclin1; tumorigenesis; c-Jun N-terminal kinase (JNK)
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Shimizu, S.; Yoshida, T.; Tsujioka, M.; Arakawa, S. Autophagic Cell Death and Cancer. Int. J. Mol. Sci. 2014, 15, 3145-3153.

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