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Int. J. Mol. Sci. 2014, 15(2), 3145-3153; doi:10.3390/ijms15023145
Review

Autophagic Cell Death and Cancer

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Received: 6 January 2014 / Revised: 10 February 2014 / Accepted: 13 February 2014 / Published: 21 February 2014
(This article belongs to the collection Programmed Cell Death and Apoptosis)
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Abstract

Programmed cell death (PCD) is a crucial process required for the normal development and physiology of metazoans. The three major mechanisms that induce PCD are called type I (apoptosis), type II (autophagic cell death), and type III (necrotic cell death). Dysfunctional PCD leads to diseases such as cancer and neurodegeneration. Although apoptosis is the most common form of PCD, recent studies have provided evidence that there are other forms of cell death. One of such cell death is autophagic cell death, which occurs via the activation of autophagy. The present review summarizes recent knowledge about autophagic cell death and discusses the relationship with tumorigenesis.
Keywords: programmed cell death; autophagic cell death; Atg5-independent autophagy; Beclin1; tumorigenesis; c-Jun N-terminal kinase (JNK) programmed cell death; autophagic cell death; Atg5-independent autophagy; Beclin1; tumorigenesis; c-Jun N-terminal kinase (JNK)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Shimizu, S.; Yoshida, T.; Tsujioka, M.; Arakawa, S. Autophagic Cell Death and Cancer. Int. J. Mol. Sci. 2014, 15, 3145-3153.

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