Int. J. Mol. Sci. 2014, 15(2), 3145-3153; doi:10.3390/ijms15023145

Autophagic Cell Death and Cancer

* email, email, email and email
Received: 6 January 2014; in revised form: 10 February 2014 / Accepted: 13 February 2014 / Published: 21 February 2014
(This article belongs to the collection Programmed Cell Death and Apoptosis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Programmed cell death (PCD) is a crucial process required for the normal development and physiology of metazoans. The three major mechanisms that induce PCD are called type I (apoptosis), type II (autophagic cell death), and type III (necrotic cell death). Dysfunctional PCD leads to diseases such as cancer and neurodegeneration. Although apoptosis is the most common form of PCD, recent studies have provided evidence that there are other forms of cell death. One of such cell death is autophagic cell death, which occurs via the activation of autophagy. The present review summarizes recent knowledge about autophagic cell death and discusses the relationship with tumorigenesis.
Keywords: programmed cell death; autophagic cell death; Atg5-independent autophagy; Beclin1; tumorigenesis; c-Jun N-terminal kinase (JNK)
PDF Full-text Download PDF Full-Text [462 KB, uploaded 19 June 2014 05:28 CEST]

Export to BibTeX |

MDPI and ACS Style

Shimizu, S.; Yoshida, T.; Tsujioka, M.; Arakawa, S. Autophagic Cell Death and Cancer. Int. J. Mol. Sci. 2014, 15, 3145-3153.

AMA Style

Shimizu S, Yoshida T, Tsujioka M, Arakawa S. Autophagic Cell Death and Cancer. International Journal of Molecular Sciences. 2014; 15(2):3145-3153.

Chicago/Turabian Style

Shimizu, Shigeomi; Yoshida, Tatsushi; Tsujioka, Masatsune; Arakawa, Satoko. 2014. "Autophagic Cell Death and Cancer." Int. J. Mol. Sci. 15, no. 2: 3145-3153.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert