Next Article in Journal
Evodiamine Induces Apoptosis and Enhances TRAIL-Induced Apoptosis in Human Bladder Cancer Cells through mTOR/S6K1-Mediated Downregulation of Mcl-1
Next Article in Special Issue
Genotoxic Anti-Cancer Agents and Their Relationship to DNA Damage, Mitosis, and Checkpoint Adaptation in Proliferating Cancer Cells
Previous Article in Journal
Genetics of Oxidative Stress in Obesity
Previous Article in Special Issue
Paclitaxel Induces Apoptosis in Breast Cancer Cells through Different Calcium—Regulating Mechanisms Depending on External Calcium Conditions
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(2), 3145-3153; doi:10.3390/ijms15023145

Autophagic Cell Death and Cancer

Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
Author to whom correspondence should be addressed.
Received: 6 January 2014 / Revised: 10 February 2014 / Accepted: 13 February 2014 / Published: 21 February 2014
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
View Full-Text   |   Download PDF [462 KB, uploaded 19 June 2014]   |  


Programmed cell death (PCD) is a crucial process required for the normal development and physiology of metazoans. The three major mechanisms that induce PCD are called type I (apoptosis), type II (autophagic cell death), and type III (necrotic cell death). Dysfunctional PCD leads to diseases such as cancer and neurodegeneration. Although apoptosis is the most common form of PCD, recent studies have provided evidence that there are other forms of cell death. One of such cell death is autophagic cell death, which occurs via the activation of autophagy. The present review summarizes recent knowledge about autophagic cell death and discusses the relationship with tumorigenesis.
Keywords: programmed cell death; autophagic cell death; Atg5-independent autophagy; Beclin1; tumorigenesis; c-Jun N-terminal kinase (JNK) programmed cell death; autophagic cell death; Atg5-independent autophagy; Beclin1; tumorigenesis; c-Jun N-terminal kinase (JNK)
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shimizu, S.; Yoshida, T.; Tsujioka, M.; Arakawa, S. Autophagic Cell Death and Cancer. Int. J. Mol. Sci. 2014, 15, 3145-3153.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top