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Open AccessCommunication
Int. J. Mol. Sci. 2014, 15(2), 2906-2915; doi:10.3390/ijms15022906

Trans-Cinnamic Acid Increases Adiponectin and the Phosphorylation of AMP-Activated Protein Kinase through G-Protein-Coupled Receptor Signaling in 3T3-L1 Adipocytes

Institute of Animal Science, Physiology & Hygiene Unit, University of Bonn, Katzenburgweg 7-9, Bonn 53115, Germany
Current address: Lohmann Animal Health GmbH, Heinz-Lohmann-Stra
Current address: Institute of Nutritional Physiology "Oskar Kellner", Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, Dummerstorf 18196, Germany.
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Author to whom correspondence should be addressed.
Received: 27 November 2013 / Revised: 24 January 2014 / Accepted: 10 February 2014 / Published: 19 February 2014
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Adiponectin and intracellular 5'adenosine monophosphate-activated protein kinase (AMPK) are important modulators of glucose and fat metabolism. Cinnamon exerts beneficial effects by improving insulin sensitivity and blood lipids, e.g., through increasing adiponectin concentrations and AMPK activation. The underlying mechanism is unknown. The Gi/Go-protein-coupled receptor (GPR) 109A stimulates adiponectin secretion after binding its ligand niacin. Trans-cinnamic acid (tCA), a compound of cinnamon is another ligand. We hypothesize whether AMPK activation and adiponectin secretion by tCA is transmitted by GPR signaling. Differentiated 3T3-L1 cells were incubated with pertussis toxin (PTX), an inhibitor of Gi/Go-protein-coupling, and treated with different tCA concentrations. Treatment with tCA increased adiponectin and the pAMPK/AMPK ratio (p ≤ 0.001). PTX incubation abolished the increased pAMPK/AMPK ratio and adiponectin secretion. The latter remained increased compared to controls (p ≤ 0.002). tCA treatment stimulated adiponectin secretion and AMPK activation; the inhibitory effect of PTX suggests GPR is involved in tCA stimulated signaling. View Full-Text
Keywords: trans-cinnamic acid; Adiponectin; 5'adenosine monophosphate-activated protein kinase; G-protein-coupled receptor 109A trans-cinnamic acid; Adiponectin; 5'adenosine monophosphate-activated protein kinase; G-protein-coupled receptor 109A
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kopp, C.; Singh, S.P.; Regenhard, P.; Müller, U.; Sauerwein, H.; Mielenz, M. Trans-Cinnamic Acid Increases Adiponectin and the Phosphorylation of AMP-Activated Protein Kinase through G-Protein-Coupled Receptor Signaling in 3T3-L1 Adipocytes. Int. J. Mol. Sci. 2014, 15, 2906-2915.

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