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Int. J. Mol. Sci. 2014, 15(12), 23377-23388; doi:10.3390/ijms151223377

RNA Recognition and Stress Granule Formation by TIA Proteins

Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
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Received: 26 October 2014 / Revised: 5 December 2014 / Accepted: 11 December 2014 / Published: 16 December 2014
(This article belongs to the Special Issue Post-Transcriptional Gene Regulation by Ribonucleoprotein Complexes)
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Abstract

Stress granule (SG) formation is a primary mechanism through which gene expression is rapidly modulated when the eukaryotic cell undergoes cellular stresses (including heat, oxidative, viral infection, starvation). In particular, the sequestration of specifically targeted translationally stalled mRNAs into SGs limits the expression of a subset of genes, but allows the expression of heatshock proteins that have a protective effect in the cell. The importance of SGs is seen in several disease states in which SG function is disrupted. Fundamental to SG formation are the T cell restricted intracellular antigen (TIA) proteins (TIA-1 and TIA-1 related protein (TIAR)), that both directly bind to target RNA and self-associate to seed the formation of SGs. Here a summary is provided of the current understanding of the way in which TIA proteins target specific mRNA, and how TIA self-association is triggered under conditions of cellular stress. View Full-Text
Keywords: RNA-binding proteins; mRNA; stress granule; translation; 5'-oligopyrimidine terminal 5'-oligopyrimidine (TOP) elements; RNA-recognition motif (RRM); T cell restricted intracellular antigen-1 (TIA-1); TIA-1 related protein (TIAR); prion-related domain (PRD) RNA-binding proteins; mRNA; stress granule; translation; 5'-oligopyrimidine terminal 5'-oligopyrimidine (TOP) elements; RNA-recognition motif (RRM); T cell restricted intracellular antigen-1 (TIA-1); TIA-1 related protein (TIAR); prion-related domain (PRD)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Waris, S.; Wilce, M.C.J.; Wilce, J.A. RNA Recognition and Stress Granule Formation by TIA Proteins. Int. J. Mol. Sci. 2014, 15, 23377-23388.

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