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Int. J. Mol. Sci. 2014, 15(10), 18084-18101; doi:10.3390/ijms151018084

The Roles of Monomeric GTP-Binding Proteins in Macroautophagy in Saccharomyces cerevisiae

Department of Biology, Georgetown University, Washington, DC 20057, USA
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Received: 6 August 2014 / Revised: 24 September 2014 / Accepted: 28 September 2014 / Published: 9 October 2014
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Abstract

Autophagy is a cellular degradation process that sequesters components into a double-membrane structure called the autophagosome, which then fuses with the lysosome or vacuole for hydrolysis and recycling of building blocks. Bulk phase autophagy, also known as macroautophagy, controlled by specific Atg proteins, can be triggered by a variety of stresses, including starvation. Because autophagy relies extensively on membrane traffic to form the membranous structures, factors that control membrane traffic are essential for autophagy. Among these factors, the monomeric GTP-binding proteins that cycle between active and inactive conformations form an important group. In this review, we summarize the functions of the monomeric GTP-binding proteins in autophagy, especially with reference to experiments in Saccharomyces cerevisiae. View Full-Text
Keywords: Baker’s yeast; monomeric GTP-binding proteins; macroautophagy Baker’s yeast; monomeric GTP-binding proteins; macroautophagy
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Yang, S.; Rosenwald, A.G. The Roles of Monomeric GTP-Binding Proteins in Macroautophagy in Saccharomyces cerevisiae. Int. J. Mol. Sci. 2014, 15, 18084-18101.

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