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Int. J. Mol. Sci. 2014, 15(10), 18040-18083; doi:10.3390/ijms151018040

Novel Formulations for Antimicrobial Peptides

Biocolloids Laboratory, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, 05508-000 São Paulo, SP, Brazil
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Received: 29 July 2014 / Revised: 30 August 2014 / Accepted: 16 September 2014 / Published: 9 October 2014
(This article belongs to the Special Issue Antimicrobial Polymers)
View Full-Text   |   Download PDF [4607 KB, uploaded 9 October 2014]   |  

Abstract

Peptides in general hold much promise as a major ingredient in novel supramolecular assemblies. They may become essential in vaccine design, antimicrobial chemotherapy, cancer immunotherapy, food preservation, organs transplants, design of novel materials for dentistry, formulations against diabetes and other important strategical applications. This review discusses how novel formulations may improve the therapeutic index of antimicrobial peptides by protecting their activity and improving their bioavailability. The diversity of novel formulations using lipids, liposomes, nanoparticles, polymers, micelles, etc., within the limits of nanotechnology may also provide novel applications going beyond antimicrobial chemotherapy. View Full-Text
Keywords: bilayer disks or fragments; liposomes; nanoparticles; biocompatible polymers; peptide covalent modification; biopolymers bilayer disks or fragments; liposomes; nanoparticles; biocompatible polymers; peptide covalent modification; biopolymers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Carmona-Ribeiro, A.M.; de Melo Carrasco, L.D. Novel Formulations for Antimicrobial Peptides. Int. J. Mol. Sci. 2014, 15, 18040-18083.

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