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Int. J. Mol. Sci. 2014, 15(10), 17938-17962; doi:10.3390/ijms151017938

Development of 3D in Vitro Technology for Medical Applications

1,2,3,4,5
and
1,2,3,4,5,6,*
1
Nanomedicine Research Center of Taiwan, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
2
Research Center for Biomedical Devices and Prototyping Production, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
3
Research Center for Biomedical Implants and Microsurgery Devices, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
4
Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
5
Department of Dentistry, Taipei Medical University-Shuang-Ho Hospital, Taipei 110, Taiwan
6
Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan
*
Author to whom correspondence should be addressed.
Received: 1 July 2014 / Revised: 16 September 2014 / Accepted: 26 September 2014 / Published: 8 October 2014
(This article belongs to the Special Issue Artificial Organs)
View Full-Text   |   Download PDF [3283 KB, uploaded 8 October 2014]   |  

Abstract

In the past few years, biomaterials technologies together with significant efforts on developing biology have revolutionized the process of engineered materials. Three dimensional (3D) in vitro technology aims to develop set of tools that are simple, inexpensive, portable and robust that could be commercialized and used in various fields of biomedical sciences such as drug discovery, diagnostic tools, and therapeutic approaches in regenerative medicine. The proliferation of cells in the 3D scaffold needs an oxygen and nutrition supply. 3D scaffold materials should provide such an environment for cells living in close proximity. 3D scaffolds that are able to regenerate or restore tissue and/or organs have begun to revolutionize medicine and biomedical science. Scaffolds have been used to support and promote the regeneration of tissues. Different processing techniques have been developed to design and fabricate three dimensional scaffolds for tissue engineering implants. Throughout the chapters we discuss in this review, we inform the reader about the potential applications of different 3D in vitro systems that can be applied for fabricating a wider range of novel biomaterials for use in tissue engineering. View Full-Text
Keywords: biomaterials; tissue engineering; 3D in vitro; polymer; hydrogel biomaterials; tissue engineering; 3D in vitro; polymer; hydrogel
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ou, K.-L.; Hosseinkhani, H. Development of 3D in Vitro Technology for Medical Applications. Int. J. Mol. Sci. 2014, 15, 17938-17962.

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