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Int. J. Mol. Sci. 2014, 15(10), 17901-17919; doi:10.3390/ijms151017901

Platelets: Still a Therapeutical Target for Haemostatic Disorders

1
Programa de Pós-graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense (UFF), Niterói CEP 24210-130, RJ, Brazil
2
Programa de Pós-graduação em Patologia, Departamento de Patologia, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Niterói CEP 24030-215, RJ, Brazil
3
LabTIF, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro CEP 21941-590, RJ, Brazil
4
Interdisciplinary Center for Biotechnology Research, Federal University of Pampa, Antônio Trilha Avenue, P.O. Box 1847, São Gabriel/RS 97300-000, Brazil
*
Authors to whom correspondence should be addressed.
Received: 19 June 2014 / Revised: 26 August 2014 / Accepted: 23 September 2014 / Published: 7 October 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [3174 KB, uploaded 24 October 2014]   |  

Abstract

Platelets are cytoplasmatic fragments from bone marrow megakaryocytes present in blood. In this work, we review the basis of platelet mechanisms, their participation in syndromes and in arterial thrombosis, and their potential as a target for designing new antithrombotic agents. The option of new biotechnological sources is also explored. View Full-Text
Keywords: platelets; agonists; receptor; thrombosis; aspirin® platelets; agonists; receptor; thrombosis; aspirin®
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Geraldo, R.B.; Sathler, P.C.; Lourenço, A.L.; Saito, M.S.; Cabral, L.M.; Rampelotto, P.H.; Castro, H.C. Platelets: Still a Therapeutical Target for Haemostatic Disorders. Int. J. Mol. Sci. 2014, 15, 17901-17919.

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