Next Article in Journal
De Novo Assembly and Characterization of Pericarp Transcriptome and Identification of Candidate Genes Mediating Fruit Cracking in Litchi chinensis Sonn.
Next Article in Special Issue
WISP1 Polymorphisms Contribute to Platinum-Based Chemotherapy Toxicity in Lung Cancer Patients
Previous Article in Journal
Expression of Root-Related Transcription Factors Associated with Flooding Tolerance of Soybean (Glycine max)
Previous Article in Special Issue
Association of CDKN2BAS Polymorphism rs4977574 with Coronary Heart Disease: A Case-Control Study and a Meta-Analysis
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(10), 17644-17666; doi:10.3390/ijms151017644

Circulating RNA Molecules as Biomarkers in Liver Disease

1,2,3,* , 2
,
1,4,5,6,7,8
,
1,4,5,6,7
,
2,3
,
2,3
and
1,4,5,6,7,8
1
Université de Lyon, Université Lyon 1, Lyon F-69008, France
2
University of Medicine and Pharmacy Tirgu Mures, 38 Gh. Marinescu st., Tirgu Mures 540142, Romania
3
Emergency County Clinical Hospital, 50 Gh. Marinescu st., Tirgu Mures 540136, Romania
4
Inserm U1111, 21 Avenue Tony Garnier, Lyon F-69007, France
5
CIRI, Centre International de Recherche en Infectiologie, Université de Lyon, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07, France
6
Ecole Normale Supérieure de Lyon, 15 parvis René Descartes, BP 7000 69342 Lyon Cedex 07, France
7
CNRS, UMR5308, 21 avenue Tony Garnier, 69365 Lyon Cedex 07, France
8
Hospices Civils de Lyon, Hôpital de la Croix Rousse, Laboratoire de Virologie, Lyon F-69004, France
*
Author to whom correspondence should be addressed.
Received: 23 August 2014 / Revised: 4 September 2014 / Accepted: 17 September 2014 / Published: 30 September 2014
(This article belongs to the Special Issue Emerging Classes of Biomarkers for Molecular Diagnostics)
View Full-Text   |   Download PDF [707 KB, uploaded 8 October 2014]

Abstract

Liver disease is a major cause of morbidity and mortality worldwide. As in other fields of medicine, there is a stringent need for non-invasive markers to improve patient diagnostics, monitoring and prognostic ability in liver pathology. Cell-free circulating RNA molecules have been recently acknowledged as an important source of potential medical biomarkers. However, many aspects related to the biology of these molecules remain to be elucidated. In this review, we summarize current concepts related to the origin, transportation and possible functions of cell-free RNA. We outline current development of extracellular RNA-based biomarkers in the main forms of non-inherited liver disease: chronic viral hepatitis, hepatocellular carcinoma, non-alcoholic fatty liver, hepato-toxicity, and liver transplantation. Despite recent technological advances, the lack of standardization in the assessment of these markers makes their adoption into clinical practice difficult. We thus finally review the main factors influencing quantification of circulating RNA. These factors should be considered in the reporting and interpretation of current findings, as well as in the proper planning of future studies, to improve reliability and reproducibility of results. View Full-Text
Keywords: liver disease; biomarker; cell-free RNA; miRNA; diagnostic; preanalytical variable liver disease; biomarker; cell-free RNA; miRNA; diagnostic; preanalytical variable
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Enache, L.S.; Enache, E.L.; Ramière, C.; Diaz, O.; Bancu, L.; Sin, A.; André, P. Circulating RNA Molecules as Biomarkers in Liver Disease. Int. J. Mol. Sci. 2014, 15, 17644-17666.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top