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Int. J. Mol. Sci. 2014, 15(11), 21011-21027; doi:10.3390/ijms151121011

WISP1 Polymorphisms Contribute to Platinum-Based Chemotherapy Toxicity in Lung Cancer Patients

1
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
2
Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China
3
The Affiliated Cancer Hospital of XiangYa School of Medicine, Central South University, Changsha 410014, China
4
Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China
5
Xiangya School of Medicine, Central South University, Changsha 410008, China
*
Author to whom correspondence should be addressed.
Received: 2 September 2014 / Revised: 28 October 2014 / Accepted: 30 October 2014 / Published: 14 November 2014
(This article belongs to the Special Issue Emerging Classes of Biomarkers for Molecular Diagnostics)
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Abstract

Platinum-based chemotherapy toxicity is always one of the serious problems from which lung cancer patients suffer. The genetic polymorphism of WISP1 was revealed to be associated with susceptibility and platinum-based chemotherapy response in our previous studies. In this study, we aimed to investigate the relationship of WISP1 genetic polymorphisms with platinum-based chemotherapy toxicity in lung cancer patients. A total of 412 lung cancer patients were enrolled in this study, and 28 polymorphisms of the WISP1 gene were genotyped by SequenomMassARRAY. We found that WISP1 polymorphisms (rs2929965, rs2929969, rs2929970, rs2929973 and rs754958) were related to the overall chemotherapy toxicity of lung cancer in subgroup analyses. Rs16904853, rs2929970, rs2977549 and rs2977551 (p = 0.021, 0.028, 0.024, 0.048, respectively) polymorphisms were significantly associated with hematologic toxicity. Rs2929946, rs2929970, rs2977519, rs2977536, rs3739262 and rs754958 (p = 0.031, 0.046, 0.029, 0.016, 0.042, 0.035, respectively) polymorphisms were significantly associated with the gastrointestinal toxicity of lung cancer. Genotypes of WISP1 may be novel and useful biomarkers for predicting platinum-based chemotherapy toxicity in lung cancer patients. View Full-Text
Keywords: WISP1; lung cancer; genetic polymorphism; chemotherapy toxicity WISP1; lung cancer; genetic polymorphism; chemotherapy toxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chen, J.; Yin, J.; Li, X.; Wang, Y.; Zheng, Y.; Qian, C.; Xiao, L.; Zou, T.; Wang, Z.; Liu, J.; Zhang, W.; Zhou, H.; Liu, Z. WISP1 Polymorphisms Contribute to Platinum-Based Chemotherapy Toxicity in Lung Cancer Patients. Int. J. Mol. Sci. 2014, 15, 21011-21027.

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