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Int. J. Mol. Sci. 2014, 15(10), 17478-17492; doi:10.3390/ijms151017478

Association of CDKN2BAS Polymorphism rs4977574 with Coronary Heart Disease: A Case-Control Study and a Meta-Analysis

1
Department of Neurosurgery, Ningbo First Hospital, Ningbo 315010, China
2
Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China
*
Authors to whom correspondence should be addressed.
Received: 22 July 2014 / Accepted: 17 September 2014 / Published: 29 September 2014
(This article belongs to the Special Issue Emerging Classes of Biomarkers for Molecular Diagnostics)
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Abstract

The goal of our study was to explore the significant association between a non-protein coding single nucleotide polymorphism (SNP) rs4977574 of CDKN2BAS gene and coronary heart disease (CHD). A total of 590 CHD cases and 482 non-CHD controls were involved in the present association study. A strong association of rs4977574 with CHD was observed in females (genotype: p = 0.002; allele: p = 0.002, odd ratio (OR) = 1.57, 95% confidential interval (CI) = 1.18–2.08). Moreover, rs4977574 was more likely to be a risk variant of CHD under the recessive model in females (χ2 = 10.29, p = 0.003, OR = 2.14, 95% CI = 1.31–2.77). A breakdown analysis by age had shown that there was an 87% increased risk of CHD for females younger than 65 years (genotype: χ2 = 14.64, degrees of freedom (df) = 2, p = 0.0002; allele: χ2 = 11.31, df = 1, p = 0.0008, OR = 1.87, 95% CI = 1.30–2.70). Similar observation was also found in males younger than 65 years (genotype: χ2 = 8.63, df = 2, p = 0.04; allele: χ2 = 7.55, df = 1, p = 0.006, OR = 1.45, 95% CI = 1.11–1.90). p values were adjusted by age, sex, smoking, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Meta-analysis of 23 studies among 36,452 cases and 39,781 controls showed a strong association between rs4977574 and the risk of CHD (p < 0.0001, OR = 1.27, 95% CI = 1.22–1.31). View Full-Text
Keywords: coronary heart disease; single nucleotide polymorphism (SNP); CDKN2BAS; meta–analysis coronary heart disease; single nucleotide polymorphism (SNP); CDKN2BAS; meta–analysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Huang, Y.; Ye, H.; Hong, Q.; Xu, X.; Jiang, D.; Xu, L.; Dai, D.; Sun, J.; Gao, X.; Duan, S. Association of CDKN2BAS Polymorphism rs4977574 with Coronary Heart Disease: A Case-Control Study and a Meta-Analysis. Int. J. Mol. Sci. 2014, 15, 17478-17492.

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