Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Int. J. Mol. Sci. 2013, 14(8), 16943-16957; doi:10.3390/ijms140816943
Article

The Association of IFI27 Expression and Fatigue Intensification during Localized Radiation Therapy: Implication of a Para-Inflammatory Bystander Response

1,2,†
, 2
, 2
 and 2,†,*
Received: 24 June 2013; in revised form: 1 August 2013 / Accepted: 5 August 2013 / Published: 16 August 2013
(This article belongs to the collection Radiation Toxicity in Cells)
View Full-Text   |   Download PDF [353 KB, uploaded 19 June 2014]
Abstract: The mechanisms behind fatigue intensification during cancer therapy remain elusive. The interferon alpha-inducible protein 27 (IFI27) was the most up-regulated gene based on our previous microarray data in fatigued men with non-metastatic prostate cancer receiving localized external beam radiation therapy (EBRT). The purpose of this study was to confirm the IFI27 up-regulation and determine its association with fatigue intensification during EBRT. Peripheral blood samples and fatigue scores were collected at three time points—prior to EBRT, at midpoint, and at completion of EBRT. Confirmatory quantitative real time polymerase chain reaction (qPCR) and enzyme-linked immunosorbent assay (ELISA) were utilized to verify the microarray results. Subjects were a total of 40 Caucasian men with prostate cancer; 20 scheduled for EBRT (65.6 ± 7.5 years old), and 20 on active surveillance as controls (62.8 ± 6.1 years old). Significant IFI27 expression overtime during EBRT was confirmed by qPCR (p < 0.5), which correlated with fatigue scores during EBRT (R = −0.90, p = 0.006). Alterations in mechanisms associated with immune response and mitochondrial function that explain the up-regulation of IFI27 may provide an understanding of the pathways related to the intensification of fatigue during localized radiation therapy.
Keywords: fatigue; gene expression; interferon; prostate cancer; radiation fatigue; gene expression; interferon; prostate cancer; radiation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Hsiao, C.-P.; Araneta, M.; Wang, X.M.; Saligan, L.N. The Association of IFI27 Expression and Fatigue Intensification during Localized Radiation Therapy: Implication of a Para-Inflammatory Bystander Response. Int. J. Mol. Sci. 2013, 14, 16943-16957.

AMA Style

Hsiao C-P, Araneta M, Wang XM, Saligan LN. The Association of IFI27 Expression and Fatigue Intensification during Localized Radiation Therapy: Implication of a Para-Inflammatory Bystander Response. International Journal of Molecular Sciences. 2013; 14(8):16943-16957.

Chicago/Turabian Style

Hsiao, Chao-Pin; Araneta, Maria; Wang, Xiao M.; Saligan, Leorey N. 2013. "The Association of IFI27 Expression and Fatigue Intensification during Localized Radiation Therapy: Implication of a Para-Inflammatory Bystander Response." Int. J. Mol. Sci. 14, no. 8: 16943-16957.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert