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Int. J. Mol. Sci. 2013, 14(8), 15376-15385; doi:10.3390/ijms140815376
Article

The L10P Polymorphism and Serum Levels of Transforming Growth Factor β1 in Human Breast Cancer

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Received: 21 June 2013; in revised form: 13 July 2013 / Accepted: 15 July 2013 / Published: 24 July 2013
(This article belongs to the Special Issue Molecular Research of Carcinogenesis)
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Abstract: The L10P single nucleotide polymorphism (SNP) is located in the signal sequence of the transforming growth factor β1 (TGFβ1) gene. The proline-encoding (Pro-) allele of this SNP has been associated with an increased breast cancer risk, which has been attributed to the elevated secretion of this TGFβ1 variant observed in vitro and in male subjects. Here we investigated the association of the L10P SNP with serum levels of TGFβ1 in female breast cancer patients and controls. We genotyped the L10P SNP in 276 breast cancer patients and 255 controls. Serum TGFβ1 concentrations were measured by enzyme-linked immunosorbent assay (ELISA) in a subset of the study population (n = 211). We found no evidence for an association of the L10P SNP with breast cancer risk (per-allele odds ratio: 0.91; 95% confidence interval: 0.71–1.16). However, patients with the Pro/Pro genotype exhibited a significantly younger age at breast cancer onset (55.2 ± 14.3 years) than Leu/Leu patients (60.6 ± 13.6 years; p = 0.04), which may reflect the ability of TGFβ to promote tumor progression. Mean TGFβ1 serum levels of Pro-allele carriers were 39.4 ± 7.4 ng/mL, whereas those of Leu/Leu subjects were 37.6 ± 6.0 ng/mL (p = 0.07). Thus, compared to a previous study of male subjects, we observed only a modest increase, if any, in TGFβ1 levels of female Pro-allele carriers.
Keywords: breast cancer; TGFβ1; rs1800470; L10P SNP; serum levels breast cancer; TGFβ1; rs1800470; L10P SNP; serum levels
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Taubenschuß, E.; Marton, E.; Mogg, M.; Frech, B.; Ehart, L.; Muin, D.; Schreiber, M. The L10P Polymorphism and Serum Levels of Transforming Growth Factor β1 in Human Breast Cancer. Int. J. Mol. Sci. 2013, 14, 15376-15385.

AMA Style

Taubenschuß E, Marton E, Mogg M, Frech B, Ehart L, Muin D, Schreiber M. The L10P Polymorphism and Serum Levels of Transforming Growth Factor β1 in Human Breast Cancer. International Journal of Molecular Sciences. 2013; 14(8):15376-15385.

Chicago/Turabian Style

Taubenschuß, Eva; Marton, Erika; Mogg, Maurice; Frech, Barbara; Ehart, Lisa; Muin, Dana; Schreiber, Martin. 2013. "The L10P Polymorphism and Serum Levels of Transforming Growth Factor β1 in Human Breast Cancer." Int. J. Mol. Sci. 14, no. 8: 15376-15385.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert