Int. J. Mol. Sci. 2013, 14(7), 14974-14995; doi:10.3390/ijms140714974
Review

Could Radiotherapy Effectiveness Be Enhanced by Electromagnetic Field Treatment?

1,2,†email, 1,†email, 1,2email, 1email, 2,3email, 1email, 1,2,4email and 1,2,5,* email
Received: 5 March 2013; in revised form: 25 June 2013 / Accepted: 1 July 2013 / Published: 17 July 2013
(This article belongs to the collection Radiation Toxicity in Cells)
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Abstract: One of the main goals in radiobiology research is to enhance radiotherapy effectiveness without provoking any increase in toxicity. In this context, it has been proposed that electromagnetic fields (EMFs), known to be modulators of proliferation rate, enhancers of apoptosis and inductors of genotoxicity, might control tumor recruitment and, thus, provide therapeutic benefits. Scientific evidence shows that the effects of ionizing radiation on cellular compartments and functions are strengthened by EMF. Although little is known about the potential role of EMFs in radiotherapy (RT), the radiosensitizing effect of EMFs described in the literature could support their use to improve radiation effectiveness. Thus, we hypothesized that EMF exposure might enhance the ionizing radiation effect on tumor cells, improving the effects of RT. The aim of this paper is to review reports of the effects of EMFs in biological systems and their potential therapeutic benefits in radiotherapy.
Keywords: electromagnetic fields; cancer; ELF magnetic exposure; radiotherapy; genotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Francisco, A.-C.; Mar, S.-A.M.; Irene, C.; Sandra, R.-A.; Josefa, L.; Elisa, R.-M.; Nicolás, O.; Isabel, N.M. Could Radiotherapy Effectiveness Be Enhanced by Electromagnetic Field Treatment? Int. J. Mol. Sci. 2013, 14, 14974-14995.

AMA Style

Francisco A-C, Mar S-AM, Irene C, Sandra R-A, Josefa L, Elisa R-M, Nicolás O, Isabel NM. Could Radiotherapy Effectiveness Be Enhanced by Electromagnetic Field Treatment? International Journal of Molecular Sciences. 2013; 14(7):14974-14995.

Chicago/Turabian Style

Francisco, Artacho-Cordón; Mar, Salinas-Asensio M.; Irene, Calvente; Sandra, Ríos-Arrabal; Josefa, León; Elisa, Román-Marinetto; Nicolás, Olea; Isabel, Núñez M. 2013. "Could Radiotherapy Effectiveness Be Enhanced by Electromagnetic Field Treatment?" Int. J. Mol. Sci. 14, no. 7: 14974-14995.


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