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Int. J. Mol. Sci. 2013, 14(7), 14974-14995; doi:10.3390/ijms140714974

Could Radiotherapy Effectiveness Be Enhanced by Electromagnetic Field Treatment?

1 Department of Radiology and Physical Medicine Av. Madrid s/n, Granada 18012, Spain 2 Biohealth Research Institute of Granada C/Doctor Azpitarte 4, fourth floor, Licinio de la Fuente Building, Granada 18012, Spain 3 Ciber of Hepatic and Digestive Diseases CIBEREHD, C/Córcega 180 ground floor, right. Barcelona 08036, Spain 4 Ciber of Epidemiology .and Public Health CIBERESP San Cecilio University Hospital, Avda Madrid s/n, Granada 18012, Spain 5 Institute of Biopathology and Regenerative Medicine (IBIMER), University of Granada. Av. Conocimiento, s/n, Armilla 18100, Granada, Spain These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 5 March 2013 / Revised: 25 June 2013 / Accepted: 1 July 2013 / Published: 17 July 2013
(This article belongs to the collection Radiation Toxicity in Cells)
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One of the main goals in radiobiology research is to enhance radiotherapy effectiveness without provoking any increase in toxicity. In this context, it has been proposed that electromagnetic fields (EMFs), known to be modulators of proliferation rate, enhancers of apoptosis and inductors of genotoxicity, might control tumor recruitment and, thus, provide therapeutic benefits. Scientific evidence shows that the effects of ionizing radiation on cellular compartments and functions are strengthened by EMF. Although little is known about the potential role of EMFs in radiotherapy (RT), the radiosensitizing effect of EMFs described in the literature could support their use to improve radiation effectiveness. Thus, we hypothesized that EMF exposure might enhance the ionizing radiation effect on tumor cells, improving the effects of RT. The aim of this paper is to review reports of the effects of EMFs in biological systems and their potential therapeutic benefits in radiotherapy.
Keywords: electromagnetic fields; cancer; ELF magnetic exposure; radiotherapy; genotoxicity electromagnetic fields; cancer; ELF magnetic exposure; radiotherapy; genotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Francisco, A.-C.; Mar, S.-A.M.; Irene, C.; Sandra, R.-A.; Josefa, L.; Elisa, R.-M.; Nicolás, O.; Isabel, N.M. Could Radiotherapy Effectiveness Be Enhanced by Electromagnetic Field Treatment? Int. J. Mol. Sci. 2013, 14, 14974-14995.

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