Melatonin Receptor Genes in Vertebrates
Abstract
:1. Introduction
2. Expression of Melatonin Receptors
3. Polymorphisms of Human Melatonin Receptor and GPR50 Genes
4. Evolution of Melatonin Receptor Genes in Vertebrates
5. Melatonin Receptors: A Perspective
Acknowledgments
Conflict of Interest
References
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Location | Gene | Length | Amino acids length | Synonymous sites | Missense sites | Frame shift sites | |
---|---|---|---|---|---|---|---|
Human | Chr: 4 | MTNR1A | 1053 bp | 351 | 21 | 27 | 0 |
Chr: 11 | MTNR1B | 1089 bp | 363 | 18 | 50 | 0 | |
Chr: X | GPR50 | 1854 bp | 618 | 9 | 21 | 3 |
Species | Mel-1a GenBank ID | Mel-1b GenBank ID | Mel-1c GenBank ID | GPR50 GenBank ID | |
---|---|---|---|---|---|
Non-mammals | Zebrafish | NM_131393.1 | NM_131395.1 | NM_001161484.1 | |
Fugu | AB492764.1 | AB492765.1 | AB492766.1 | ||
Frog | XP_002940910.1 | U09561.1 | |||
Chicken | NM_205362.1 | XM_417201.2 | NM_205361.1 | ||
Zebra finch | NM_001048257.1 | NM_001048258.1 | XM_002193412.1 | ||
Mammals | Horse | XP_001490221.1 | XM_001917051.1 | ||
Gorilla gorilla | XM_004040725.1 | XM_004051965.1 | |||
Cat | XM_003984615.1 | XM_003992620.1 | |||
Human | NM_005958.3 | NM_005959.3 | NM_004224.3 | ||
Chimpanzee | XM_526799.2 | XM_522146.4 | |||
Rat | NM_053676.2 | NM_001100641.1 | NM_001191915.1 | ||
Dog | XM_540019.3 | XM_844629.2 | |||
Mouse | NM_008639.2 | NM_145712.2 | NM_010340.1 | ||
Cow | XM_002698656.1 | NM_001206907.1 | |||
Sheep | NP_001009725.1 | NM_001130938.1 | NM_001009726.1 |
Zebrafish | Cat | Chicken | Chimpanzee | Cow | Dog | Frog | Fugu | Gorilla | Horse | Human | Mouse | Rat | Sheep | Zebrafinch | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Zebrafish | 0.014 | 0.014 | 0.014 | 0.013 | 0.013 | 0.013 | 0.012 | 0.014 | 0.013 | 0.014 | 0.014 | 0.013 | 0.014 | 0.013 | |
Cat | 0.333 | 0.014 | 0.012 | 0.012 | 0.011 | 0.014 | 0.013 | 0.012 | 0.012 | 0.012 | 0.012 | 0.012 | 0.013 | 0.014 | |
Chicken | 0.276 | 0.286 | 0.014 | 0.012 | 0.012 | 0.012 | 0.013 | 0.013 | 0.013 | 0.013 | 0.013 | 0.013 | 0.013 | 0.009 | |
Chimpanzee | 0.302 | 0.182 | 0.289 | 0.013 | 0.012 | 0.014 | 0.013 | 0.009 | 0.012 | 0.008 | 0.012 | 0.012 | 0.013 | 0.014 | |
Cow | 0.297 | 0.188 | 0.260 | 0.210 | 0.011 | 0.013 | 0.013 | 0.011 | 0.011 | 0.011 | 0.012 | 0.011 | 0.005 | 0.012 | |
Dog | 0.281 | 0.153 | 0.219 | 0.196 | 0.146 | 0.013 | 0.012 | 0.010 | 0.009 | 0.010 | 0.010 | 0.010 | 0.011 | 0.012 | |
Frog | 0.287 | 0.310 | 0.211 | 0.315 | 0.271 | 0.258 | 0.013 | 0.013 | 0.013 | 0.013 | 0.013 | 0.013 | 0.014 | 0.012 | |
Fugu | 0.202 | 0.312 | 0.275 | 0.285 | 0.279 | 0.276 | 0.299 | 0.012 | 0.012 | 0.012 | 0.013 | 0.013 | 0.013 | 0.013 | |
Gorilla | 0.275 | 0.187 | 0.239 | 0.075 | 0.152 | 0.135 | 0.266 | 0.243 | 0.010 | 0.003 | 0.010 | 0.011 | 0.011 | 0.013 | |
Horse | 0.274 | 0.175 | 0.235 | 0.200 | 0.140 | 0.100 | 0.262 | 0.267 | 0.139 | 0.010 | 0.011 | 0.010 | 0.011 | 0.013 | |
Human | 0.276 | 0.187 | 0.239 | 0.074 | 0.152 | 0.138 | 0.268 | 0.244 | 0.007 | 0.137 | 0.011 | 0.011 | 0.011 | 0.013 | |
Mouse | 0.292 | 0.222 | 0.249 | 0.221 | 0.186 | 0.161 | 0.257 | 0.264 | 0.169 | 0.147 | 0.169 | 0.009 | 0.012 | 0.013 | |
Rat | 0.289 | 0.233 | 0.250 | 0.219 | 0.181 | 0.164 | 0.258 | 0.268 | 0.166 | 0.152 | 0.166 | 0.082 | 0.011 | 0.013 | |
Sheep | 0.292 | 0.202 | 0.258 | 0.216 | 0.029 | 0.150 | 0.276 | 0.279 | 0.159 | 0.145 | 0.159 | 0.192 | 0.187 | 0.013 | |
Zebrafinch | 0.276 | 0.282 | 0.102 | 0.296 | 0.256 | 0.235 | 0.210 | 0.269 | 0.251 | 0.244 | 0.249 | 0.263 | 0.265 | 0.258 |
Zebrafish | Cat | Chicken | Chimpanzee | Cow | Dog | Fugu | Gorilla | Horse | Human | Mouse | Rat | Sheep | Zebrafinch | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Zebrafish | 0.014 | 0.014 | 0.014 | 0.014 | 0.016 | 0.014 | 0.014 | 0.014 | 0.014 | 0.014 | 0.014 | 0.014 | 0.015 | |
Cat | 0.367 | 0.015 | 0.011 | 0.011 | 0.012 | 0.014 | 0.011 | 0.011 | 0.011 | 0.012 | 0.012 | 0.012 | 0.015 | |
Chicken | 0.359 | 0.316 | 0.014 | 0.014 | 0.015 | 0.015 | 0.014 | 0.014 | 0.014 | 0.015 | 0.014 | 0.014 | 0.008 | |
Chimpanzee | 0.361 | 0.138 | 0.307 | 0.011 | 0.013 | 0.015 | 0.004 | 0.011 | 0.003 | 0.013 | 0.013 | 0.011 | 0.014 | |
Cow | 0.358 | 0.178 | 0.337 | 0.171 | 0.013 | 0.015 | 0.011 | 0.011 | 0.011 | 0.012 | 0.013 | 0.005 | 0.014 | |
Dog | 0.420 | 0.182 | 0.371 | 0.216 | 0.272 | 0.016 | 0.013 | 0.013 | 0.013 | 0.014 | 0.014 | 0.014 | 0.015 | |
Fugu | 0.329 | 0.338 | 0.347 | 0.334 | 0.339 | 0.389 | 0.014 | 0.015 | 0.014 | 0.014 | 0.015 | 0.014 | 0.015 | |
Gorilla | 0.362 | 0.139 | 0.306 | 0.019 | 0.170 | 0.221 | 0.333 | 0.011 | 0.003 | 0.013 | 0.013 | 0.012 | 0.013 | |
Horse | 0.364 | 0.133 | 0.303 | 0.131 | 0.173 | 0.210 | 0.325 | 0.133 | 0.011 | 0.012 | 0.012 | 0.011 | 0.014 | |
Human | 0.358 | 0.135 | 0.306 | 0.015 | 0.167 | 0.219 | 0.330 | 0.012 | 0.128 | 0.013 | 0.013 | 0.012 | 0.013 | |
Mouse | 0.381 | 0.192 | 0.338 | 0.190 | 0.240 | 0.288 | 0.357 | 0.191 | 0.201 | 0.191 | 0.009 | 0.013 | 0.015 | |
Rat | 0.380 | 0.200 | 0.340 | 0.202 | 0.250 | 0.284 | 0.358 | 0.203 | 0.206 | 0.204 | 0.095 | 0.013 | 0.014 | |
Sheep | 0.372 | 0.180 | 0.346 | 0.170 | 0.034 | 0.268 | 0.337 | 0.171 | 0.171 | 0.166 | 0.239 | 0.247 | 0.014 | |
Zebrafinch | 0.370 | 0.317 | 0.071 | 0.311 | 0.338 | 0.376 | 0.352 | 0.311 | 0.305 | 0.307 | 0.330 | 0.336 | 0.343 |
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Li, D.Y.; Smith, D.G.; Hardeland, R.; Yang, M.Y.; Xu, H.L.; Zhang, L.; Yin, H.D.; Zhu, Q. Melatonin Receptor Genes in Vertebrates. Int. J. Mol. Sci. 2013, 14, 11208-11223. https://doi.org/10.3390/ijms140611208
Li DY, Smith DG, Hardeland R, Yang MY, Xu HL, Zhang L, Yin HD, Zhu Q. Melatonin Receptor Genes in Vertebrates. International Journal of Molecular Sciences. 2013; 14(6):11208-11223. https://doi.org/10.3390/ijms140611208
Chicago/Turabian StyleLi, Di Yan, David Glenn Smith, Rüdiger Hardeland, Ming Yao Yang, Huai Liang Xu, Long Zhang, Hua Dong Yin, and Qing Zhu. 2013. "Melatonin Receptor Genes in Vertebrates" International Journal of Molecular Sciences 14, no. 6: 11208-11223. https://doi.org/10.3390/ijms140611208