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Characterization and Antimicrobial Property of Poly(Acrylic Acid) Nanogel Containing Silver Particle Prepared by Electron Beam
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong Jeongeup-si, Jeollabuk-do 580-185, Korea
Department of Organic Materials and Fibers Engineering, Chonbuk National University, Jeonju 561-756, Korea
* Author to whom correspondence should be addressed.
Received: 26 March 2013; in revised form: 30 April 2013 / Accepted: 2 May 2013 / Published: 24 May 2013
Abstract: In this study, we developed a one step process to synthesize nanogel containing silver nanoparticles involving electron beam irradiation. Water-soluble silver nitrate powder is dissolved in the distilled water and then poly(acrylic acid) (PAAc) and hexane are put into this silver nitrate solution. These samples are irradiated by an electron beam to make the PAAc nanogels containing silver nanoparticles (Ag/PAAc nanogels). The nanoparticles were characterized by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). In addition, the particle size and zeta-potential were confirmed by a particle size analyzer (PSA). The antibacterial properties of the nanogels were evaluated by paper diffusion test. The Ag/PAAc nanogels had an antibacterial effect against Escherichia coli and Staphylococcus aureus. The nanogels also demonstrated a good healing effect against diabetic ulcer. The size of the Ag/PAAc nanogels decreased with increasing irradiation doses, and the absolute value of the zeta potential increased with increasing irradiation doses. Also, the Ag/PAAc nanogels exhibited good antibacterial activity against both Gram-negative and Gram-positive bacteria. In in vivo wound healing, the Ag/PAAc nanogels have a good healing effect.
Keywords: nanogel; poly(acrylic acid); silver nanoparticle; antimicrobial property
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MDPI and ACS Style
Choi, J.-B.; Park, J.-S.; Khil, M.-S.; Gwon, H.-J.; Lim, Y.-M.; Jeong, S.-I.; Shin, Y.-M.; Nho, Y.-C. Characterization and Antimicrobial Property of Poly(Acrylic Acid) Nanogel Containing Silver Particle Prepared by Electron Beam. Int. J. Mol. Sci. 2013, 14, 11011-11023.
Choi J-B, Park J-S, Khil M-S, Gwon H-J, Lim Y-M, Jeong S-I, Shin Y-M, Nho Y-C. Characterization and Antimicrobial Property of Poly(Acrylic Acid) Nanogel Containing Silver Particle Prepared by Electron Beam. International Journal of Molecular Sciences. 2013; 14(6):11011-11023.
Choi, Jong-Bae; Park, Jong-Seok; Khil, Myung-Seob; Gwon, Hui-Jeong; Lim, Youn-Mook; Jeong, Sung-In; Shin, Young-Min; Nho, Young-Chang. 2013. "Characterization and Antimicrobial Property of Poly(Acrylic Acid) Nanogel Containing Silver Particle Prepared by Electron Beam." Int. J. Mol. Sci. 14, no. 6: 11011-11023.