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Chemoresistance Is Associated with MUC1 and Lewis y Antigen Expression in Ovarian Epithelial Cancers
Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 17 April 2013; in revised form: 9 May 2013 / Accepted: 13 May 2013 / Published: 24 May 2013
Abstract: Objective: The aim of this study was to analyze the correlation and clinical significance between the expression of Mucin-1 (MUC1) and the Lewis y antigen with chemoresistance in ovarian epithelial cancers. Methods: Ovarian cancer patients (n = 92) treated at our hospital from May 2005 to July 2009 were divided, according to their treatment and follow-up outcomes, into a resistant group (n = 37) or sensitive group (n = 55). The expression of MUC1 and Lewis y antigen in ovarian cancer tissues was detected using immunohistochemistry and correlated with chemoresistance. Results: The positive rates of MUC1 and Lewis y antigen in the resistant group were both 91.89%, significantly higher than their positive rates in the sensitive group (65.45% and 69.09%, respectively, and both p < 0.05). MUC1 or Lewis y expression and the pathological stage of the tissue were independent risk factors for chemoresistance (all p < 0.05). Conclusion: The increased expression of MUC1 and the Lewis y antigen is a significant risk factor for chemoresistance in patients with ovarian epithelial cancer.
Keywords: ovarian epithelial cancer; MUC1; Lewis y antigen; chemoresistance; immunohistochemistry
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Zhang, D.; Gao, J.; Zhu, L.; Hu, Z.; Hou, R.; Liu, S.; Tan, M.; Liu, J.; Lin, B. Chemoresistance Is Associated with MUC1 and Lewis y Antigen Expression in Ovarian Epithelial Cancers. Int. J. Mol. Sci. 2013, 14, 11024-11033.
Zhang D, Gao J, Zhu L, Hu Z, Hou R, Liu S, Tan M, Liu J, Lin B. Chemoresistance Is Associated with MUC1 and Lewis y Antigen Expression in Ovarian Epithelial Cancers. International Journal of Molecular Sciences. 2013; 14(6):11024-11033.
Zhang, Danye; Gao, Jian; Zhu, Liancheng; Hu, Zhenhua; Hou, Rui; Liu, Shuice; Tan, Mingzi; Liu, Juanjuan; Lin, Bei. 2013. "Chemoresistance Is Associated with MUC1 and Lewis y Antigen Expression in Ovarian Epithelial Cancers." Int. J. Mol. Sci. 14, no. 6: 11024-11033.