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Int. J. Mol. Sci. 2013, 14(5), 9767-9778; doi:10.3390/ijms14059767

Oenothein B Suppresses Lipopolysaccharide (LPS)-Induced Inflammation in the Mouse Brain

1
Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan
2
Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan
*
Author to whom correspondence should be addressed.
Received: 7 April 2013 / Revised: 28 April 2013 / Accepted: 2 May 2013 / Published: 7 May 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Oenothein B has been recently evaluated for its ability to affect inflammatory responses in peripheral tissues. In this study, we examined its effect on the damage to the central nervous system due to systemic inflammation. For this purpose, ICR mice were injected with an intraperitoneal (i.p.) dose of lipopolysaccharide (LPS; 1 mg/kg mouse). When oenothein B was administered per os (p.o.), it suppressed (1) LPS-induced abnormal behavior in open field; (2) LPS-induced microglial activation in the hippocampus and striatum; and (3) LPS-induced cyclooxygenase (COX)-2 production in the hippocampus and striatum of these mice. These results suggest that oenothein B had the ability to reduce neuroinflammation in the brain during systemic inflammation.
Keywords: oenothein B; lipopolysaccharide; depression-like behavior; hippocampus; inflammation; microglia; COX-2; astrocyte oenothein B; lipopolysaccharide; depression-like behavior; hippocampus; inflammation; microglia; COX-2; astrocyte
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Okuyama, S.; Makihata, N.; Yoshimura, M.; Amakura, Y.; Yoshida, T.; Nakajima, M.; Furukawa, Y. Oenothein B Suppresses Lipopolysaccharide (LPS)-Induced Inflammation in the Mouse Brain. Int. J. Mol. Sci. 2013, 14, 9767-9778.

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