Int. J. Mol. Sci. 2013, 14(5), 10591-10607; doi:10.3390/ijms140510591

Nanoparticle-Based Systems for T1-Weighted Magnetic Resonance Imaging Contrast Agents

1email, 2email, 2,* email, 2email and 2,* email
Received: 18 March 2013; in revised form: 9 May 2013 / Accepted: 13 May 2013 / Published: 21 May 2013
(This article belongs to the Special Issue Magnetic Nanoparticles 2013)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Because magnetic resonance imaging (MRI) contrast agents play a vital role in diagnosing diseases, demand for new MRI contrast agents, with an enhanced sensitivity and advanced functionalities, is very high. During the past decade, various inorganic nanoparticles have been used as MRI contrast agents due to their unique properties, such as large surface area, easy surface functionalization, excellent contrasting effect, and other size-dependent properties. This review provides an overview of recent progress in the development of nanoparticle-based T1-weighted MRI contrast agents. The chemical synthesis of the nanoparticle-based contrast agents and their potential applications were discussed and summarized. In addition, the recent development in nanoparticle-based multimodal contrast agents including T1-weighted MRI/computed X-ray tomography (CT) and T1-weighted MRI/optical were also described, since nanoparticles may curtail the shortcomings of single mode contrast agents in diagnostic and clinical settings by synergistically incorporating functionality.
Keywords: T1-weighted magnetic resonance; molecular imaging; nanoparticles; contrast agents
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MDPI and ACS Style

Zhu, D.; Liu, F.; Ma, L.; Liu, D.; Wang, Z. Nanoparticle-Based Systems for T1-Weighted Magnetic Resonance Imaging Contrast Agents. Int. J. Mol. Sci. 2013, 14, 10591-10607.

AMA Style

Zhu D, Liu F, Ma L, Liu D, Wang Z. Nanoparticle-Based Systems for T1-Weighted Magnetic Resonance Imaging Contrast Agents. International Journal of Molecular Sciences. 2013; 14(5):10591-10607.

Chicago/Turabian Style

Zhu, Derong; Liu, Fuyao; Ma, Lina; Liu, Dianjun; Wang, Zhenxin. 2013. "Nanoparticle-Based Systems for T1-Weighted Magnetic Resonance Imaging Contrast Agents." Int. J. Mol. Sci. 14, no. 5: 10591-10607.

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