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Nanoparticle-Based Systems for T1-Weighted Magnetic Resonance Imaging Contrast Agents
Department of Medicinal Chemistry and Pharmaceutical Analysis, Guangdong Medical College, Dongwan 523770, Guangdong, China
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China
* Authors to whom correspondence should be addressed.
Received: 18 March 2013; in revised form: 9 May 2013 / Accepted: 13 May 2013 / Published: 21 May 2013
Abstract: Because magnetic resonance imaging (MRI) contrast agents play a vital role in diagnosing diseases, demand for new MRI contrast agents, with an enhanced sensitivity and advanced functionalities, is very high. During the past decade, various inorganic nanoparticles have been used as MRI contrast agents due to their unique properties, such as large surface area, easy surface functionalization, excellent contrasting effect, and other size-dependent properties. This review provides an overview of recent progress in the development of nanoparticle-based T1-weighted MRI contrast agents. The chemical synthesis of the nanoparticle-based contrast agents and their potential applications were discussed and summarized. In addition, the recent development in nanoparticle-based multimodal contrast agents including T1-weighted MRI/computed X-ray tomography (CT) and T1-weighted MRI/optical were also described, since nanoparticles may curtail the shortcomings of single mode contrast agents in diagnostic and clinical settings by synergistically incorporating functionality.
Keywords: T1-weighted magnetic resonance; molecular imaging; nanoparticles; contrast agents
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MDPI and ACS Style
Zhu, D.; Liu, F.; Ma, L.; Liu, D.; Wang, Z. Nanoparticle-Based Systems for T1-Weighted Magnetic Resonance Imaging Contrast Agents. Int. J. Mol. Sci. 2013, 14, 10591-10607.
Zhu D, Liu F, Ma L, Liu D, Wang Z. Nanoparticle-Based Systems for T1-Weighted Magnetic Resonance Imaging Contrast Agents. International Journal of Molecular Sciences. 2013; 14(5):10591-10607.
Zhu, Derong; Liu, Fuyao; Ma, Lina; Liu, Dianjun; Wang, Zhenxin. 2013. "Nanoparticle-Based Systems for T1-Weighted Magnetic Resonance Imaging Contrast Agents." Int. J. Mol. Sci. 14, no. 5: 10591-10607.