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Antibacterial Activity of the Alkaloid-Enriched Extract from Prosopis juliflora Pods and Its Influence on in Vitro Ruminal Digestion
Department of Instrumental and Basic Studies, State University of Southeast of Bahia, BR 415, Km 03, s/n, 45.700-000 Itapetinga, Bahia, Brazil
Department of Exact and Earth Sciences, University of Bahia, Rua Silveira Martins, 2555, Cabula, 41150-000 Salvador, Bahia, Brazil
Chemistry Institute, Federal University of Bahia, Rua Barão de Geremoabo, s/n, Ondina, 40170-290 Salvador, Bahia, Brazil
Chemistry and Biotechnology Institute, Federal University of Alagoas, Cidade Universitária, BR 101, Km 14, Norte Tabuleiro dos Martins, 57072-970 Maceió, Alagoas, Brazil
Chemistry Department, Federal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, Campus Pampulha, 31270-901, Belo Horizonte, MG, Brazil
Department of Fundamental Chemistry, Chemistry Institute, University of São Paulo, 05508-000 São Paulo-SP, Brazil
Department of Plant and Animal Science, State University of Southeast of Bahia, Estrada do Bem Querer, Km 04, s/n, 45.083-900 Vitória da Conquista, Bahia, Brazil
Department of Exact and Technological Sciences, State University of Santa Cruz, Rodovia Ilhéus/Itabuna, Km 16, Salobrinho, 45662-900 Ilhéus, Bahia, Brazil
* Author to whom correspondence should be addressed.
Received: 8 October 2012; in revised form: 17 January 2013 / Accepted: 20 March 2013 / Published: 17 April 2013
Abstract: The purpose of this study was to assess the in vitro antimicrobial activity of alkaloid-enriched extracts from Prosopis juliflora (Fabaceae) pods in order to evaluate them as feed additives for ruminants. As only the basic chloroformic extract (BCE), whose main constituents were juliprosopine (juliflorine), prosoflorine and juliprosine, showed Gram-positive antibacterial activity against Micrococcus luteus (MIC = 25 μg/mL), Staphylococcus aureus (MIC = 50 μg/mL) and Streptococcus mutans (MIC = 50 μg/mL), its influence on ruminal digestion was evaluated using a semi-automated in vitro gas production technique, with monensin as the positive control. Results showed that BCE has decreased gas production as efficiently as monensin after 36 h of fermentation, revealing its positive influence on gas production during ruminal digestion. Since P. juliflora is a very affordable plant, this study points out this alkaloid enriched extract from the pods of Prosopis juliflora as a potential feed additive to decrease gas production during ruminal digestion.
Keywords: antibacterial activity; Prosopis juliflora pods; juliprosopine (juliflorine); prosoflorine; juliprosine; in vitro ruminal digestion; feed additives
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dos Santos, E.T.; Pereira, M.L.A.; da Silva, C.F.P.; Souza-Neta, L.C.; Geris, R.; Martins, D.; Santana, A.E.G.; Barbosa, L.C.A.; Silva, H.G.O.; Freitas, G.C.; Figueiredo, M.P.; de Oliveira, F.F.; Batista, R. Antibacterial Activity of the Alkaloid-Enriched Extract from Prosopis juliflora Pods and Its Influence on in Vitro Ruminal Digestion. Int. J. Mol. Sci. 2013, 14, 8496-8516.
dos Santos ET, Pereira MLA, da Silva CFP, Souza-Neta LC, Geris R, Martins D, Santana AEG, Barbosa LCA, Silva HGO, Freitas GC, Figueiredo MP, de Oliveira FF, Batista R. Antibacterial Activity of the Alkaloid-Enriched Extract from Prosopis juliflora Pods and Its Influence on in Vitro Ruminal Digestion. International Journal of Molecular Sciences. 2013; 14(4):8496-8516.
dos Santos, Edilene T.; Pereira, Mara L.A.; da Silva, Camilla F.P.; Souza-Neta, Lourdes C.; Geris, Regina; Martins, Dirceu; Santana, Antônio E.G.; Barbosa, Luiz C.A.; Silva, Herymá G.O.; Freitas, Giovana C.; Figueiredo, Mauro P.; de Oliveira, Fernando F.; Batista, Ronan. 2013. "Antibacterial Activity of the Alkaloid-Enriched Extract from Prosopis juliflora Pods and Its Influence on in Vitro Ruminal Digestion." Int. J. Mol. Sci. 14, no. 4: 8496-8516.