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Aberrant Free Radical Biology Is a Unifying Theme in the Etiology and Pathogenesis of Major Human Diseases
Departments of Radiation Oncology, Surgery, and Pathology; Carver College of Medicine, the University of Iowa, Iowa City, IA 52242, USA
Received: 1 April 2013; in revised form: 16 April 2013 / Accepted: 16 April 2013 / Published: 17 April 2013
Abstract: The seemingly disparate areas of oxygen toxicity, radiation exposure, and aging are now recognized to share a common feature—the aberrant production and/or removal of biologically derived free radicals and other reactive oxygen and nitrogen species (ROS/RNS). Advances in our understanding of the effects of free radicals in biology and medicine have been, and continue to be, actively translated into clinically tractable diagnostic and therapeutic applications. This issue is dedicated to recent advances, both basic discoveries and clinical applications, in the field of free radicals in biology and medicine. As more is understood about the proximal biological targets of aberrantly produced or removed reactive species, their sensors, and effectors of compensatory response, a great deal more will be learned about the commonalities in mechanisms underlying seemingly disparate disease states. Together with this deeper understanding, opportunities will arise to devise rational therapeutic interventions to decrease the incidence and severity of these diseases and positively impact the human healthspan.
Keywords: mitochondria; oxidative stress; reactive oxygen; nitric oxide; free radicals; cancer; diabetes; vascular disease; neurodegenerative disease; aging
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Domann, F.E. Aberrant Free Radical Biology Is a Unifying Theme in the Etiology and Pathogenesis of Major Human Diseases. Int. J. Mol. Sci. 2013, 14, 8491-8495.
Domann FE. Aberrant Free Radical Biology Is a Unifying Theme in the Etiology and Pathogenesis of Major Human Diseases. International Journal of Molecular Sciences. 2013; 14(4):8491-8495.
Domann, Frederick E. 2013. "Aberrant Free Radical Biology Is a Unifying Theme in the Etiology and Pathogenesis of Major Human Diseases." Int. J. Mol. Sci. 14, no. 4: 8491-8495.