Next Article in Journal
Antibacterial Activity of the Alkaloid-Enriched Extract from Prosopis juliflora Pods and Its Influence on in Vitro Ruminal Digestion
Previous Article in Journal
Identification of a Genomic Region Containing a Novel Promoter Resistant to Glucose Repression and Over-Expression of β-Glucosidase Gene in Hypocrea orientalis EU7-22
Previous Article in Special Issue
Oxidative Stress in Complex Regional Pain Syndrome (CRPS): No Systemically Elevated Levels of Malondialdehyde, F2-Isoprostanes and 8OHdG in a Selected Sample of Patients
Int. J. Mol. Sci. 2013, 14(4), 8491-8495; doi:10.3390/ijms14048491
Editorial

Aberrant Free Radical Biology Is a Unifying Theme in the Etiology and Pathogenesis of Major Human Diseases

Received: 1 April 2013; in revised form: 16 April 2013 / Accepted: 16 April 2013 / Published: 17 April 2013
(This article belongs to the Special Issue Advances in Free Radicals in Biology and Medicine)
View Full-Text   |   Download PDF [385 KB, uploaded 19 June 2014]   |   Browse Figure
Abstract: The seemingly disparate areas of oxygen toxicity, radiation exposure, and aging are now recognized to share a common feature—the aberrant production and/or removal of biologically derived free radicals and other reactive oxygen and nitrogen species (ROS/RNS). Advances in our understanding of the effects of free radicals in biology and medicine have been, and continue to be, actively translated into clinically tractable diagnostic and therapeutic applications. This issue is dedicated to recent advances, both basic discoveries and clinical applications, in the field of free radicals in biology and medicine. As more is understood about the proximal biological targets of aberrantly produced or removed reactive species, their sensors, and effectors of compensatory response, a great deal more will be learned about the commonalities in mechanisms underlying seemingly disparate disease states. Together with this deeper understanding, opportunities will arise to devise rational therapeutic interventions to decrease the incidence and severity of these diseases and positively impact the human healthspan.
Keywords: mitochondria; oxidative stress; reactive oxygen; nitric oxide; free radicals; cancer; diabetes; vascular disease; neurodegenerative disease; aging mitochondria; oxidative stress; reactive oxygen; nitric oxide; free radicals; cancer; diabetes; vascular disease; neurodegenerative disease; aging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Domann, F.E. Aberrant Free Radical Biology Is a Unifying Theme in the Etiology and Pathogenesis of Major Human Diseases. Int. J. Mol. Sci. 2013, 14, 8491-8495.

AMA Style

Domann FE. Aberrant Free Radical Biology Is a Unifying Theme in the Etiology and Pathogenesis of Major Human Diseases. International Journal of Molecular Sciences. 2013; 14(4):8491-8495.

Chicago/Turabian Style

Domann, Frederick E. 2013. "Aberrant Free Radical Biology Is a Unifying Theme in the Etiology and Pathogenesis of Major Human Diseases." Int. J. Mol. Sci. 14, no. 4: 8491-8495.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert