Next Article in Journal
The Importance of the PI3K/AKT/MTOR Pathway in the Progression of Ovarian Cancer
Next Article in Special Issue
Two Common Bean Genotypes with Contrasting Response to Phosphorus Deficiency Show Variations in the microRNA 399-Mediated PvPHO2 Regulation within the PvPHR1 Signaling Pathway
Previous Article in Journal
Advances in the Techniques for the Prediction of microRNA Targets
Previous Article in Special Issue
Role of Homeodomain Leucine Zipper (HD-Zip) IV Transcription Factors in Plant Development and Plant Protection from Deleterious Environmental Factors
Int. J. Mol. Sci. 2013, 14(4), 8188-8212; doi:10.3390/ijms14048188
Review

Endoplasmic Reticulum (ER) Stress Response and Its Physiological Roles in Plants

,
 and
*
Plant Sciences Institute and Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA
* Author to whom correspondence should be addressed.
Received: 16 February 2013 / Revised: 19 March 2013 / Accepted: 1 April 2013 / Published: 15 April 2013
(This article belongs to the Special Issue Abiotic and Biotic Stress Tolerance Mechanisms in Plants)
View Full-Text   |   Download PDF [859 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

The endoplasmic reticulum (ER) stress response is a highly conserved mechanism that results from the accumulation of unfolded or misfolded proteins in the ER. The response plays an important role in allowing plants to sense and respond to adverse environmental conditions, such as heat stress, salt stress and pathogen infection. Since the ER is a well-controlled microenvironment for proper protein synthesis and folding, it is highly susceptible to stress conditions. Accumulation of unfolded or misfolded proteins activates a signaling pathway, called the unfolded protein response (UPR), which acts to relieve ER stress and, if unsuccessful, leads to cell death. Plants have two arms of the UPR signaling pathway, an arm involving the proteolytic processing of membrane-associated basic leucine zipper domain (bZIP) transcription factors and an arm involving RNA splicing factor, IRE1, and its mRNA target. These signaling pathways play an important role in determining the cell’s fate in response to stress conditions.
Keywords: endoplasmic reticulum stress; unfolded protein response (UPR); endoplasmic reticulum quality control (ERQC); endoplasmic reticulum associated degradation (ERAD); autophagy; cell death endoplasmic reticulum stress; unfolded protein response (UPR); endoplasmic reticulum quality control (ERQC); endoplasmic reticulum associated degradation (ERAD); autophagy; cell death
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Deng, Y.; Srivastava, R.; Howell, S.H. Endoplasmic Reticulum (ER) Stress Response and Its Physiological Roles in Plants. Int. J. Mol. Sci. 2013, 14, 8188-8212.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert