Int. J. Mol. Sci. 2013, 14(3), 5920-5937; doi:10.3390/ijms14035920
Review

Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster

email and * email
Received: 1 February 2013; in revised form: 5 March 2013 / Accepted: 12 March 2013 / Published: 14 March 2013
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Intercellular signalling via growth factors plays an important role in controlling cell differentiation and cell movements during the development of multicellular animals. Fibroblast Growth Factor (FGF) signalling induces changes in cellular behaviour allowing cells in the embryo to move, to survive, to divide or to differentiate. Several examples argue that FGF signalling is used in multi-step morphogenetic processes to achieve and maintain a transitional state of the cells required for the control of cell fate. In the genetic model Drosophila melanogaster, FGF signalling via the receptor tyrosine kinases Heartless (Htl) and Breathless (Btl) is particularly well studied. These FGF receptors affect gene expression, cell shape and cell–cell interactions during mesoderm layer formation, caudal visceral muscle (CVM) formation, tracheal morphogenesis and glia differentiation. Here, we will address the current knowledge of the biological functions of FGF signalling in the fly on the tissue, at a cellular and molecular level.
Keywords: fibroblast growth factor; development; cell signalling; cell migration; differentiation; Drosophila
PDF Full-text Download PDF Full-Text [381 KB, uploaded 19 June 2014 04:46 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Muha, V.; Müller, H.-A.J. Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster. Int. J. Mol. Sci. 2013, 14, 5920-5937.

AMA Style

Muha V, Müller H-AJ. Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster. International Journal of Molecular Sciences. 2013; 14(3):5920-5937.

Chicago/Turabian Style

Muha, Villö; Müller, Hans-Arno J. 2013. "Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster." Int. J. Mol. Sci. 14, no. 3: 5920-5937.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert