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Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster
Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD15EH, Scotland, UK
* Author to whom correspondence should be addressed.
Received: 1 February 2013; in revised form: 5 March 2013 / Accepted: 12 March 2013 / Published: 14 March 2013
Abstract: Intercellular signalling via growth factors plays an important role in controlling cell differentiation and cell movements during the development of multicellular animals. Fibroblast Growth Factor (FGF) signalling induces changes in cellular behaviour allowing cells in the embryo to move, to survive, to divide or to differentiate. Several examples argue that FGF signalling is used in multi-step morphogenetic processes to achieve and maintain a transitional state of the cells required for the control of cell fate. In the genetic model Drosophila melanogaster, FGF signalling via the receptor tyrosine kinases Heartless (Htl) and Breathless (Btl) is particularly well studied. These FGF receptors affect gene expression, cell shape and cell–cell interactions during mesoderm layer formation, caudal visceral muscle (CVM) formation, tracheal morphogenesis and glia differentiation. Here, we will address the current knowledge of the biological functions of FGF signalling in the fly on the tissue, at a cellular and molecular level.
Keywords: fibroblast growth factor; development; cell signalling; cell migration; differentiation; Drosophila
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Muha, V.; Müller, H.-A.J. Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster. Int. J. Mol. Sci. 2013, 14, 5920-5937.
Muha V, Müller H-AJ. Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster. International Journal of Molecular Sciences. 2013; 14(3):5920-5937.
Muha, Villö; Müller, Hans-Arno J. 2013. "Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster." Int. J. Mol. Sci. 14, no. 3: 5920-5937.