Int. J. Mol. Sci. 2013, 14(3), 5501-5518; doi:10.3390/ijms14035501
Review

Understanding Resolvin Signaling Pathways to Improve Oral Health

David Keinan 1,2 email, Noel J. Leigh 2 email, Joel W. Nelson 2 email, Laura De Oleo 2 email and Olga J. Baker 2,* email
1 Department of Periodontics and Endodontics, School of Dental Medicine, University at Buffalo, the State University of New York, Buffalo, NY 14214-3932, USA 2 Department of Oral Biology, School of Dental Medicine, University at Buffalo, the State University of New York, Buffalo, NY 14214-3932, USA
* Author to whom correspondence should be addressed.
Received: 31 December 2012; in revised form: 19 February 2013 / Accepted: 22 February 2013 / Published: 8 March 2013
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
PDF Full-text Download PDF Full-Text [540 KB, uploaded 8 March 2013 11:19 CET]
Abstract: The discovery of resolvins has been a major breakthrough for understanding the processes involved in resolution of inflammation. Resolvins belong to a family of novel lipid mediators that possess dual anti-inflammatory and pro-resolution actions. Specifically, they protect healthy tissue during immune-inflammatory responses to infection or injury, thereby aiding inflammation resolution and promoting tissue healing. One of the major concerns in modern medicine is the management and treatment of oral diseases, as they are related to systemic outcomes impacting the quality of life of many patients. This review summarizes known signaling pathways utilized by resolvins to regulate inflammatory responses associated with the oral cavity.
Keywords: oral; resolvin; signaling pathways; inflammation

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Keinan, D.; Leigh, N.J.; Nelson, J.W.; De Oleo, L.; Baker, O.J. Understanding Resolvin Signaling Pathways to Improve Oral Health. Int. J. Mol. Sci. 2013, 14, 5501-5518.

AMA Style

Keinan D, Leigh NJ, Nelson JW, De Oleo L, Baker OJ. Understanding Resolvin Signaling Pathways to Improve Oral Health. International Journal of Molecular Sciences. 2013; 14(3):5501-5518.

Chicago/Turabian Style

Keinan, David; Leigh, Noel J.; Nelson, Joel W.; De Oleo, Laura; Baker, Olga J. 2013. "Understanding Resolvin Signaling Pathways to Improve Oral Health." Int. J. Mol. Sci. 14, no. 3: 5501-5518.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert