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Understanding Resolvin Signaling Pathways to Improve Oral Health
Department of Periodontics and Endodontics, School of Dental Medicine, University at Buffalo, the State University of New York, Buffalo, NY 14214-3932, USA
Department of Oral Biology, School of Dental Medicine, University at Buffalo, the State University of New York, Buffalo, NY 14214-3932, USA
* Author to whom correspondence should be addressed.
Received: 31 December 2012; in revised form: 19 February 2013 / Accepted: 22 February 2013 / Published: 8 March 2013
Abstract: The discovery of resolvins has been a major breakthrough for understanding the processes involved in resolution of inflammation. Resolvins belong to a family of novel lipid mediators that possess dual anti-inflammatory and pro-resolution actions. Specifically, they protect healthy tissue during immune-inflammatory responses to infection or injury, thereby aiding inflammation resolution and promoting tissue healing. One of the major concerns in modern medicine is the management and treatment of oral diseases, as they are related to systemic outcomes impacting the quality of life of many patients. This review summarizes known signaling pathways utilized by resolvins to regulate inflammatory responses associated with the oral cavity.
Keywords: oral; resolvin; signaling pathways; inflammation
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Cite This Article
MDPI and ACS Style
Keinan, D.; Leigh, N.J.; Nelson, J.W.; De Oleo, L.; Baker, O.J. Understanding Resolvin Signaling Pathways to Improve Oral Health. Int. J. Mol. Sci. 2013, 14, 5501-5518.
Keinan D, Leigh NJ, Nelson JW, De Oleo L, Baker OJ. Understanding Resolvin Signaling Pathways to Improve Oral Health. International Journal of Molecular Sciences. 2013; 14(3):5501-5518.
Keinan, David; Leigh, Noel J.; Nelson, Joel W.; De Oleo, Laura; Baker, Olga J. 2013. "Understanding Resolvin Signaling Pathways to Improve Oral Health." Int. J. Mol. Sci. 14, no. 3: 5501-5518.