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Int. J. Mol. Sci. 2013, 14(3), 5501-5518; doi:10.3390/ijms14035501

Understanding Resolvin Signaling Pathways to Improve Oral Health

Received: 31 December 2012 / Revised: 19 February 2013 / Accepted: 22 February 2013 / Published: 8 March 2013
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
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The discovery of resolvins has been a major breakthrough for understanding the processes involved in resolution of inflammation. Resolvins belong to a family of novel lipid mediators that possess dual anti-inflammatory and pro-resolution actions. Specifically, they protect healthy tissue during immune-inflammatory responses to infection or injury, thereby aiding inflammation resolution and promoting tissue healing. One of the major concerns in modern medicine is the management and treatment of oral diseases, as they are related to systemic outcomes impacting the quality of life of many patients. This review summarizes known signaling pathways utilized by resolvins to regulate inflammatory responses associated with the oral cavity.
Keywords: oral; resolvin; signaling pathways; inflammation oral; resolvin; signaling pathways; inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keinan, D.; Leigh, N.J.; Nelson, J.W.; De Oleo, L.; Baker, O.J. Understanding Resolvin Signaling Pathways to Improve Oral Health. Int. J. Mol. Sci. 2013, 14, 5501-5518.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert