Int. J. Mol. Sci. 2013, 14(3), 5367-5379; doi:10.3390/ijms14035367

Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis

1 Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA 2 Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
* Author to whom correspondence should be addressed.
Received: 30 January 2013; in revised form: 21 February 2013 / Accepted: 26 February 2013 / Published: 6 March 2013
(This article belongs to the Special Issue Genes and Pathways in the Pathogenesis of Ovarian Cancer)
PDF Full-text Download PDF Full-Text [186 KB, uploaded 6 March 2013 12:09 CET]
Abstract: Endometriosis is classically defined as the presence of endometrial glands and stroma outside of the endometrial lining and uterine musculature. With an estimated frequency of 5%–10% among women of reproductive age, endometriosis is a common gynecologic disorder. While in itself a benign lesion, endometriosis shares several characteristics with invasive cancer, has been shown to undergo malignant transformation, and has been associated with an increased risk of epithelial ovarian carcinoma (EOC). Numerous epidemiologic studies have shown an increased risk of EOC among women with endometriosis. This is particularly true for women with endometrioid and clear cell ovarian carcinoma. However, the carcinogenic pathways by which endometriosis associated ovarian carcinoma (EAOC) develops remain poorly understood. Current molecular studies have sought to link endometriosis with EAOC through pathways related to oxidative stress, inflammation and hyperestrogenism. In addition, numerous studies have sought to identify an intermediary lesion between endometriosis and EAOC that may allow for the identification of endometriosis at greatest risk for malignant transformation or for the prevention of malignant transformation of this common gynecologic disorder. The objective of the current article is to review the current data regarding the molecular events associated with EAOC development from endometriosis, with a primary focus on malignancies of the endometrioid and clear cell histologic sub-types.
Keywords: endometriosis; epithelial ovarian carcinoma; malignant transformation

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Worley, M.J., Jr.; Welch, W.R.; Berkowitz, R.S.; Ng, S.-W. Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis. Int. J. Mol. Sci. 2013, 14, 5367-5379.

AMA Style

Worley MJ, Jr, Welch WR, Berkowitz RS, Ng S-W. Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis. International Journal of Molecular Sciences. 2013; 14(3):5367-5379.

Chicago/Turabian Style

Worley, Michael J., Jr.; Welch, William R.; Berkowitz, Ross S.; Ng, Shu-Wing. 2013. "Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis." Int. J. Mol. Sci. 14, no. 3: 5367-5379.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert