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Int. J. Mol. Sci. 2013, 14(3), 5380-5401; doi:10.3390/ijms14035380

Roles of Melatonin in Fetal Programming in Compromised Pregnancies

, 1
, 1
, 1,2
 and 1,3,*
Received: 17 February 2013 / Revised: 25 February 2013 / Accepted: 25 February 2013 / Published: 6 March 2013
(This article belongs to the Special Issue Advances in the Research of Melatonin)
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Abstract: Compromised pregnancies such as those associated with gestational diabetes mellitus, intrauterine growth retardation, preeclampsia, maternal undernutrition, and maternal stress may negatively affect fetal development. Such pregnancies may induce oxidative stress to the fetus and alter fetal development through the epigenetic process that may affect development at a later stage. Melatonin is an oxidant scavenger that reverses oxidative stress during the prenatal period. Moreover, the role of melatonin in epigenetic modifications in the field of developmental programming has been studied extensively. Here, we describe the physiological function of melatonin in pregnancy and discuss the roles of melatonin in fetal programming in compromised pregnancies, focusing on its involvement in redox and epigenetic mechanisms.
Keywords: melatonin; epigenetic; fetal programming; redox; pregnancy melatonin; epigenetic; fetal programming; redox; pregnancy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, Y.-C.; Sheen, J.-M.; Tiao, M.-M.; Tain, Y.-L.; Huang, L.-T. Roles of Melatonin in Fetal Programming in Compromised Pregnancies. Int. J. Mol. Sci. 2013, 14, 5380-5401.

AMA Style

Chen Y-C, Sheen J-M, Tiao M-M, Tain Y-L, Huang L-T. Roles of Melatonin in Fetal Programming in Compromised Pregnancies. International Journal of Molecular Sciences. 2013; 14(3):5380-5401.

Chicago/Turabian Style

Chen, Yu-Chieh; Sheen, Jiunn-Ming; Tiao, Miao-Meng; Tain, You-Lin; Huang, Li-Tung. 2013. "Roles of Melatonin in Fetal Programming in Compromised Pregnancies." Int. J. Mol. Sci. 14, no. 3: 5380-5401.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert