Int. J. Mol. Sci. 2013, 14(3), 4982-5012; doi:10.3390/ijms14034982

p53 and Ceramide as Collaborators in the Stress Response

1,2,* email, 1,2email, 2email and 1,2email
Received: 26 December 2012; in revised form: 22 January 2013 / Accepted: 1 February 2013 / Published: 1 March 2013
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The sphingolipid ceramide mediates various cellular processes in response to several extracellular stimuli. Some genotoxic stresses are able to induce p53-dependent ceramide accumulation leading to cell death. However, in other cases, in the absence of the tumor suppressor protein p53, apoptosis proceeds partly due to the activity of this “tumor suppressor lipid”, ceramide. In the current review, we describe ceramide and its roles in signaling pathways such as cell cycle arrest, hypoxia, hyperoxia, cell death, and cancer. In a specific manner, we are elaborating on the role of ceramide in mitochondrial apoptotic cell death signaling. Furthermore, after highlighting the role and mechanism of action of p53 in apoptosis, we review the association of ceramide and p53 with respect to apoptosis. Strikingly, the hypothesis for a direct interaction between ceramide and p53 is less favored. Recent data suggest that ceramide can act either upstream or downstream of p53 protein through posttranscriptional regulation or through many potential mediators, respectively.
Keywords: ceramide; p53; apoptosis; sphingolipids; mitochondria; signaling; Bcl2 family; caspase
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MDPI and ACS Style

Hage-Sleiman, R.; Esmerian, M.O.; Kobeissy, H.; Dbaibo, G. p53 and Ceramide as Collaborators in the Stress Response. Int. J. Mol. Sci. 2013, 14, 4982-5012.

AMA Style

Hage-Sleiman R, Esmerian MO, Kobeissy H, Dbaibo G. p53 and Ceramide as Collaborators in the Stress Response. International Journal of Molecular Sciences. 2013; 14(3):4982-5012.

Chicago/Turabian Style

Hage-Sleiman, Rouba; Esmerian, Maria O.; Kobeissy, Hadile; Dbaibo, Ghassan. 2013. "p53 and Ceramide as Collaborators in the Stress Response." Int. J. Mol. Sci. 14, no. 3: 4982-5012.

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