Int. J. Mol. Sci. 2013, 14(2), 4030-4049; doi:10.3390/ijms14024030
Review

The Role of F-Box Proteins during Viral Infection

1email, 2email, 1,2email and 2,* email
Received: 23 October 2012; in revised form: 14 December 2012 / Accepted: 17 January 2013 / Published: 18 February 2013
(This article belongs to the Special Issue Advances in Molecular Plant Biology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The F-box domain is a protein structural motif of about 50 amino acids that mediates protein–protein interactions. The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. Several discoveries have been made on the use of the ubiquitin–proteasome system by viruses of several families to complete their infection cycle. On the other hand, F-box proteins can be used in the defense response by the host. This review describes the role of F-box proteins and the use of the ubiquitin–proteasome system in virus–host interactions.
Keywords: F-box; SCF complex; virus–host interactions; viral infection
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MDPI and ACS Style

Correa, R.L.; Bruckner, F.P.; de Souza Cascardo, R.; Alfenas-Zerbini, P. The Role of F-Box Proteins during Viral Infection. Int. J. Mol. Sci. 2013, 14, 4030-4049.

AMA Style

Correa RL, Bruckner FP, de Souza Cascardo R, Alfenas-Zerbini P. The Role of F-Box Proteins during Viral Infection. International Journal of Molecular Sciences. 2013; 14(2):4030-4049.

Chicago/Turabian Style

Correa, Régis L.; Bruckner, Fernanda P.; de Souza Cascardo, Renan; Alfenas-Zerbini, Poliane. 2013. "The Role of F-Box Proteins during Viral Infection." Int. J. Mol. Sci. 14, no. 2: 4030-4049.


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