Next Article in Journal
The Role of Lipid Domains in Bacterial Cell Processes
Next Article in Special Issue
Identification and Phylogenetic Analysis of a CC-NBS-LRR Encoding Gene Assigned on Chromosome 7B of Wheat
Previous Article in Journal
Theoretical and Experimental Spectroscopic Analysis of Cyano-Substituted Styrylpyridine Compounds
Previous Article in Special Issue
The Characterization of SaPIN2b, a Plant Trichome-Localized Proteinase Inhibitor from Solanum americanum
Int. J. Mol. Sci. 2013, 14(2), 4030-4049; doi:10.3390/ijms14024030
Review

The Role of F-Box Proteins during Viral Infection

1
,
2
,
1,2
 and
2,*
1 Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21944-970, Brazil 2 Department of Microbiology/BIOAGRO, Federal University of Viçosa, Viçosa, MG 36570-000, Brazil
* Author to whom correspondence should be addressed.
Received: 23 October 2012 / Revised: 14 December 2012 / Accepted: 17 January 2013 / Published: 18 February 2013
(This article belongs to the Special Issue Advances in Molecular Plant Biology)
View Full-Text   |   Download PDF [207 KB, uploaded 19 June 2014]

Abstract

The F-box domain is a protein structural motif of about 50 amino acids that mediates protein–protein interactions. The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. Several discoveries have been made on the use of the ubiquitin–proteasome system by viruses of several families to complete their infection cycle. On the other hand, F-box proteins can be used in the defense response by the host. This review describes the role of F-box proteins and the use of the ubiquitin–proteasome system in virus–host interactions.
Keywords: F-box; SCF complex; virus–host interactions; viral infection F-box; SCF complex; virus–host interactions; viral infection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Correa, R.L.; Bruckner, F.P.; de Souza Cascardo, R.; Alfenas-Zerbini, P. The Role of F-Box Proteins during Viral Infection. Int. J. Mol. Sci. 2013, 14, 4030-4049.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert