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Int. J. Mol. Sci. 2013, 14(2), 3285-3313; doi:10.3390/ijms14023285
Review

Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions

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Received: 9 December 2012; in revised form: 21 January 2013 / Accepted: 23 January 2013 / Published: 5 February 2013
(This article belongs to the Special Issue Phospholipids: Molecular Sciences 2012)
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Abstract: Non-enzymatic modification of aminophospholipids by lipid peroxidation-derived aldehydes and reducing sugars through carbonyl-amine reactions are thought to contribute to the age-related deterioration of cellular membranes and to the pathogenesis of diabetic complications. Much evidence demonstrates the modification of aminophospholipids by glycation, glycoxidation and lipoxidation reactions. Therefore, a number of early and advanced Maillard reaction-lipid products have been detected and quantified in different biological membranes. These modifications may be accumulated during aging and diabetes, introducing changes in cell membrane physico-chemical and biological properties.
Keywords: advanced glycation endproducts; advanced lipoxidation endproducts; age-associated diseases; aging; cell membrane; carbonyl compounds; lipid peroxidation; Maillard reaction products; oxidative stress; phosphatidylethanolamine; phosphatidylserine advanced glycation endproducts; advanced lipoxidation endproducts; age-associated diseases; aging; cell membrane; carbonyl compounds; lipid peroxidation; Maillard reaction products; oxidative stress; phosphatidylethanolamine; phosphatidylserine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Naudí, A.; Jové, M.; Ayala, V.; Cabré, R.; Portero-Otín, M.; Pamplona, R. Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions. Int. J. Mol. Sci. 2013, 14, 3285-3313.

AMA Style

Naudí A, Jové M, Ayala V, Cabré R, Portero-Otín M, Pamplona R. Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions. International Journal of Molecular Sciences. 2013; 14(2):3285-3313.

Chicago/Turabian Style

Naudí, Alba; Jové, Mariona; Ayala, Victòria; Cabré, Rosanna; Portero-Otín, Manuel; Pamplona, Reinald. 2013. "Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions." Int. J. Mol. Sci. 14, no. 2: 3285-3313.


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