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Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions
Department of Experimental Medicine, Faculty of Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida E25198, Catalonia, Spain
* Author to whom correspondence should be addressed.
Received: 9 December 2012; in revised form: 21 January 2013 / Accepted: 23 January 2013 / Published: 5 February 2013
Abstract: Non-enzymatic modification of aminophospholipids by lipid peroxidation-derived aldehydes and reducing sugars through carbonyl-amine reactions are thought to contribute to the age-related deterioration of cellular membranes and to the pathogenesis of diabetic complications. Much evidence demonstrates the modification of aminophospholipids by glycation, glycoxidation and lipoxidation reactions. Therefore, a number of early and advanced Maillard reaction-lipid products have been detected and quantified in different biological membranes. These modifications may be accumulated during aging and diabetes, introducing changes in cell membrane physico-chemical and biological properties.
Keywords: advanced glycation endproducts; advanced lipoxidation endproducts; age-associated diseases; aging; cell membrane; carbonyl compounds; lipid peroxidation; Maillard reaction products; oxidative stress; phosphatidylethanolamine; phosphatidylserine
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Naudí, A.; Jové, M.; Ayala, V.; Cabré, R.; Portero-Otín, M.; Pamplona, R. Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions. Int. J. Mol. Sci. 2013, 14, 3285-3313.
Naudí A, Jové M, Ayala V, Cabré R, Portero-Otín M, Pamplona R. Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions. International Journal of Molecular Sciences. 2013; 14(2):3285-3313.
Naudí, Alba; Jové, Mariona; Ayala, Victòria; Cabré, Rosanna; Portero-Otín, Manuel; Pamplona, Reinald. 2013. "Non-Enzymatic Modification of Aminophospholipids by Carbonyl-Amine Reactions." Int. J. Mol. Sci. 14, no. 2: 3285-3313.