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Int. J. Mol. Sci. 2013, 14(2), 2551-2558; doi:10.3390/ijms14022551

Yeast α-Glucosidase Inhibitory Phenolic Compounds Isolated from Gynura medica Leaf

* ,
The First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, Hubei, China
* Author to whom correspondence should be addressed.
Received: 10 December 2012 / Revised: 16 January 2013 / Accepted: 21 January 2013 / Published: 28 January 2013
(This article belongs to the Special Issue Plant-Derived Pharmaceuticals by Molecular Farming 2012)
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Gynura medica leaf extract contains significant amounts of flavonols and phenolic acids and exhibits powerful hypoglycemic activity against diabetic rats in vivo. However, the hypoglycemic active constituents that exist in the plant have not been fully elaborated. The purpose of this study is to isolate and elaborate the hypoglycemic activity compounds against inhibition the yeast α-glucosidase in vitro. Seven phenolic compounds including five flavonols and two phenolic acids were isolated from the leaf of G. medica. Their structures were identified by the extensive NMR and mass spectral analyses as: kaempferol (1), quercetin (2), kaempferol-3-O-β-D-glucopyranoside (3), kaempferol-3-O-rutinoside (4), rutin (5), chlorogenic acid (6) and 3,5-dicaffeoylquinic acid methyl ester (7). All of the compounds except 1 and 3 were isolated for the first time from G. medica. Compounds 17 were also assayed for their hypoglycemic activity against yeast α-glucosidase in vitro. All of the compounds except 1 and 6 showed good yeast α-glucosidase inhibitory activity with the IC50 values of 1.67 mg/mL, 1.46 mg/mL, 0.38 mg/mL, 0.10 mg/mL and 0.53 mg/mL, respectively.
Keywords: Gynura medica; yeast α-glucosidase; flavonols; phenolic acids Gynura medica; yeast α-glucosidase; flavonols; phenolic acids
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Tan, C.; Wang, Q.; Luo, C.; Chen, S.; Li, Q.; Li, P. Yeast α-Glucosidase Inhibitory Phenolic Compounds Isolated from Gynura medica Leaf. Int. J. Mol. Sci. 2013, 14, 2551-2558.

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