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Production of Pharmaceutical Proteins in Solanaceae Food Crops
Department of Agricultural Sciences, University of Naples "Federico II", Via Università 100, Portici 80055, Naples, Italy
School of Biological Sciences, Monash University, Clayton, Victoria 3800, Australia
* Author to whom correspondence should be addressed.
Received: 3 December 2012; in revised form: 11 January 2013 / Accepted: 22 January 2013 / Published: 29 January 2013
Abstract: The benefits of increased safety and cost-effectiveness make vegetable crops appropriate systems for the production and delivery of pharmaceutical proteins. In particular, Solanaceae edible crops could be inexpensive biofactories for oral vaccines and other pharmaceutical proteins that can be ingested as minimally processed extracts or as partially purified products. The field of crop plant biotechnology is advancing rapidly due to novel developments in genetic and genomic tools being made available today for the scientific community. In this review, we briefly summarize data now available regarding genomic resources for the Solanaceae family. In addition, we describe novel strategies developed for the expression of foreign proteins in vegetable crops and the utilization of these techniques to manufacture pharmaceutical proteins.
Keywords: plant-made vaccines; Solanaceae; transgenic plant; food crop
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Rigano, M.M.; De Guzman, G.; Walmsley, A.M.; Frusciante, L.; Barone, A. Production of Pharmaceutical Proteins in Solanaceae Food Crops. Int. J. Mol. Sci. 2013, 14, 2753-2773.
Rigano MM, De Guzman G, Walmsley AM, Frusciante L, Barone A. Production of Pharmaceutical Proteins in Solanaceae Food Crops. International Journal of Molecular Sciences. 2013; 14(2):2753-2773.
Rigano, Maria M.; De Guzman, Giorgio; Walmsley, Amanda M.; Frusciante, Luigi; Barone, Amalia. 2013. "Production of Pharmaceutical Proteins in Solanaceae Food Crops." Int. J. Mol. Sci. 14, no. 2: 2753-2773.