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Int. J. Mol. Sci. 2013, 14(2), 2502-2514; https://doi.org/10.3390/ijms14022502

Melatonin May Curtail the Metabolic Syndrome: Studies on Initial and Fully Established Fructose-Induced Metabolic Syndrome in Rats

1
Department of Teaching and Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, 1107 Buenos Aires, Argentina
2
Department of Physiology, Faculty of Medicine, University of Buenos Aires, 1121 Buenos Aires, Argentina
*
Author to whom correspondence should be addressed.
Received: 24 December 2012 / Revised: 15 January 2013 / Accepted: 22 January 2013 / Published: 25 January 2013
(This article belongs to the Special Issue Advances in the Research of Melatonin)
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Abstract

To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly under both treatments whereas excessive body weight was seen in rats receiving the 10% fructose only. Rats drinking 5% fructose showed a greater tolerance to a glucose load while rats having access to a 10% fructose drinking solution exhibited the expected impaired glucose tolerance found in the metabolic syndrome. Circulating triglyceride and low density lipoproteins-cholesterol (LDL-c) concentration augmented significantly in rats showing a fully developed metabolic syndrome only, while high blood cholesterol levels were found at both stages examined. Melatonin (25 μg/mL drinking solution) counteracted the changes in body weight and systolic blood pressure found in rats administered with fructose. Melatonin decreased the abnormal hyperglycemia seen after a glucose load in 10% fructose-treated rats but it did not modify the greater tolerance to glucose observed in animals drinking 5% fructose. Melatonin also counteracted the changes in plasma LDL-c, triglyceride and cholesterol levels and decreased plasma uric acid levels. The results underline a possible therapeutical role of melatonin in the metabolic syndrome, both at initial and established phases. View Full-Text
Keywords: metabolic syndrome; melatonin; fructose; dyslipidemia; hypertension; obesity; glucose tolerance metabolic syndrome; melatonin; fructose; dyslipidemia; hypertension; obesity; glucose tolerance
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Cardinali, D.P.; Bernasconi, P.A.S.; Reynoso, R.; Toso, C.F.R.; Scacchi, P. Melatonin May Curtail the Metabolic Syndrome: Studies on Initial and Fully Established Fructose-Induced Metabolic Syndrome in Rats. Int. J. Mol. Sci. 2013, 14, 2502-2514.

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