Abstract: To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly under both treatments whereas excessive body weight was seen in rats receiving the 10% fructose only. Rats drinking 5% fructose showed a greater tolerance to a glucose load while rats having access to a 10% fructose drinking solution exhibited the expected impaired glucose tolerance found in the metabolic syndrome. Circulating triglyceride and low density lipoproteins-cholesterol (LDL-c) concentration augmented significantly in rats showing a fully developed metabolic syndrome only, while high blood cholesterol levels were found at both stages examined. Melatonin (25 μg/mL drinking solution) counteracted the changes in body weight and systolic blood pressure found in rats administered with fructose. Melatonin decreased the abnormal hyperglycemia seen after a glucose load in 10% fructose-treated rats but it did not modify the greater tolerance to glucose observed in animals drinking 5% fructose. Melatonin also counteracted the changes in plasma LDL-c, triglyceride and cholesterol levels and decreased plasma uric acid levels. The results underline a possible therapeutical role of melatonin in the metabolic syndrome, both at initial and established phases.
Keywords: metabolic syndrome; melatonin; fructose; dyslipidemia; hypertension; obesity; glucose tolerance
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Cardinali, D.P.; Bernasconi, P.A.S.; Reynoso, R.; Toso, C.F.R.; Scacchi, P. Melatonin May Curtail the Metabolic Syndrome: Studies on Initial and Fully Established Fructose-Induced Metabolic Syndrome in Rats. Int. J. Mol. Sci. 2013, 14, 2502-2514.
Cardinali DP, Bernasconi PAS, Reynoso R, Toso CFR, Scacchi P. Melatonin May Curtail the Metabolic Syndrome: Studies on Initial and Fully Established Fructose-Induced Metabolic Syndrome in Rats. International Journal of Molecular Sciences. 2013; 14(2):2502-2514.
Cardinali, Daniel P.; Bernasconi, Pablo A.S.; Reynoso, Roxana; Toso, Carlos F.R.; Scacchi, Pablo. 2013. "Melatonin May Curtail the Metabolic Syndrome: Studies on Initial and Fully Established Fructose-Induced Metabolic Syndrome in Rats." Int. J. Mol. Sci. 14, no. 2: 2502-2514.