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Int. J. Mol. Sci. 2013, 14(12), 24064-24073; doi:10.3390/ijms141224064
Article

Synthesis and Larvicidal Activity against Culex pipiens pallens of New Triazole Derivatives of Phrymarolin from Phryma leptostachya L.

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Received: 28 October 2013 / Revised: 22 November 2013 / Accepted: 3 December 2013 / Published: 10 December 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Twelve new triazole derivatives of Phrymarolin were prepared from Phrymarolin I and the structures of all the derivatives were fully characterized by 1H-NMR, 13C-NMR and MS spectral data analyses. Larvicidal activities against 4rd instar larvae of Culex pipiens pallens of these Phrymarolin analogues were assayed. Although the triazole derivatives of Phrymarolin showed certain larvicidal activity, they showed lower activity than Phrymarolin I. The typical non-natural groups triazole substituents reduced the larvicidal activity of Phrymarolin derivatives.
Keywords: Phryma leptostachya L.; triazole; larvicidal activity; Culex pipiens pallens Phryma leptostachya L.; triazole; larvicidal activity; Culex pipiens pallens
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, J.-W.; Hu, Z.; Gao, P.; Wang, J.-R.; Hu, Z.-N.; Wu, W.-J. Synthesis and Larvicidal Activity against Culex pipiens pallens of New Triazole Derivatives of Phrymarolin from Phryma leptostachya L.. Int. J. Mol. Sci. 2013, 14, 24064-24073.

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