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Int. J. Mol. Sci. 2013, 14(12), 23910-23921; doi:10.3390/ijms141223910
Article

Rheumatoid Arthritis-Associated MicroRNA-155 Targets SOCS1 and Upregulates TNF-α and IL-1β in PBMCs

* ,
 and
The Department of Hand & Foot Surgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110001, China
* Author to whom correspondence should be addressed.
Received: 25 September 2013 / Revised: 13 November 2013 / Accepted: 19 November 2013 / Published: 9 December 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

miR-155 plays a crucial role in proinflammatory activation. This study was carried out to assess the association of abnormal expression of miR-155 in peripheral blood of patients with Rheumatoid arthritis with the expression of TNF-α and IL-1β. Release of TNF-α and IL-1β, and expression of miR-155 were determined in RA peripheral blood or peripheral blood macrophages, followed by correlation analysis of the cytokines release and miR-155 expression. Furthermore, in vitro studies indicate that miR-155 inhibited the expression of SOCS1. Our results suggest that there is a correlation between the high-level expression of miR-155 and the enhanced expression of TNF-α and IL-1β. miR-155 targets and suppresses the expression of SOCS1, and the decrease of SOCS1 may lead to the upregulation of TNF-α and IL-1β.
Keywords: miR-155; rheumatoid arthritis; TNF-α and IL-1β; SOCS1 miR-155; rheumatoid arthritis; TNF-α and IL-1β; SOCS1
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Li, X.; Tian, F.; Wang, F. Rheumatoid Arthritis-Associated MicroRNA-155 Targets SOCS1 and Upregulates TNF-α and IL-1β in PBMCs. Int. J. Mol. Sci. 2013, 14, 23910-23921.

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