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Int. J. Mol. Sci. 2013, 14(12), 23910-23921; doi:10.3390/ijms141223910
Article

Rheumatoid Arthritis-Associated MicroRNA-155 Targets SOCS1 and Upregulates TNF-α and IL-1β in PBMCs

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Received: 25 September 2013; in revised form: 13 November 2013 / Accepted: 19 November 2013 / Published: 9 December 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: miR-155 plays a crucial role in proinflammatory activation. This study was carried out to assess the association of abnormal expression of miR-155 in peripheral blood of patients with Rheumatoid arthritis with the expression of TNF-α and IL-1β. Release of TNF-α and IL-1β, and expression of miR-155 were determined in RA peripheral blood or peripheral blood macrophages, followed by correlation analysis of the cytokines release and miR-155 expression. Furthermore, in vitro studies indicate that miR-155 inhibited the expression of SOCS1. Our results suggest that there is a correlation between the high-level expression of miR-155 and the enhanced expression of TNF-α and IL-1β. miR-155 targets and suppresses the expression of SOCS1, and the decrease of SOCS1 may lead to the upregulation of TNF-α and IL-1β.
Keywords: miR-155; rheumatoid arthritis; TNF-α and IL-1β; SOCS1 miR-155; rheumatoid arthritis; TNF-α and IL-1β; SOCS1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Li, X.; Tian, F.; Wang, F. Rheumatoid Arthritis-Associated MicroRNA-155 Targets SOCS1 and Upregulates TNF-α and IL-1β in PBMCs. Int. J. Mol. Sci. 2013, 14, 23910-23921.

AMA Style

Li X, Tian F, Wang F. Rheumatoid Arthritis-Associated MicroRNA-155 Targets SOCS1 and Upregulates TNF-α and IL-1β in PBMCs. International Journal of Molecular Sciences. 2013; 14(12):23910-23921.

Chicago/Turabian Style

Li, Xiaochuan; Tian, Feng; Wang, Fei. 2013. "Rheumatoid Arthritis-Associated MicroRNA-155 Targets SOCS1 and Upregulates TNF-α and IL-1β in PBMCs." Int. J. Mol. Sci. 14, no. 12: 23910-23921.



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