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Int. J. Mol. Sci. 2013, 14(11), 22906-22932; doi:10.3390/ijms141122906
Review

New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein

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Received: 22 September 2013; in revised form: 13 November 2013 / Accepted: 13 November 2013 / Published: 20 November 2013
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Abstract: Polypyrimidine Tract Binding Protein (PTB) is an intensely studied RNA binding protein involved in several post-transcriptional regulatory events of gene expression. Initially described as a pre-mRNA splicing regulator, PTB is now widely accepted as a multifunctional protein shuttling between nucleus and cytoplasm. Accordingly, PTB can interact with selected RNA targets, structural elements and proteins. There is increasing evidence that PTB and its paralog PTBP2 play a major role as repressors of alternatively spliced exons, whose transcription is tissue-regulated. In addition to alternative splicing, PTB is involved in almost all steps of mRNA metabolism, including polyadenylation, mRNA stability and initiation of protein translation. Furthermore, it is well established that PTB recruitment in internal ribosome entry site (IRES) activates the translation of picornaviral and cellular proteins. Detailed studies of the structural properties of PTB have contributed to our understanding of the mechanism of RNA binding by RNA Recognition Motif (RRM) domains. In the present review, we will describe the structural properties of PTB, its paralogs and co-factors, the role in post-transcriptional regulation and actions in cell differentiation and pathogenesis. Defining the multifunctional roles of PTB will contribute to the understanding of key regulatory events in gene expression.
Keywords: PTB; raver1; alternative splicing; IRES; RRM; RNA binding proteins; ribonucleoproteins; hnRNP; mRNA stability; cell differentiation PTB; raver1; alternative splicing; IRES; RRM; RNA binding proteins; ribonucleoproteins; hnRNP; mRNA stability; cell differentiation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Romanelli, M.G.; Diani, E.; Lievens, P.M.-J. New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein. Int. J. Mol. Sci. 2013, 14, 22906-22932.

AMA Style

Romanelli MG, Diani E, Lievens PM-J. New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein. International Journal of Molecular Sciences. 2013; 14(11):22906-22932.

Chicago/Turabian Style

Romanelli, Maria G.; Diani, Erica; Lievens, Patricia M.-J. 2013. "New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein." Int. J. Mol. Sci. 14, no. 11: 22906-22932.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert