Int. J. Mol. Sci. 2013, 14(11), 22117-22131; doi:10.3390/ijms141122117

The Ribonucleoprotein Csr Network

Laboratoire de Génétique et Physiologie Bactérienne, IBMM, Faculté des Sciences, Université Libre de Bruxelles (ULB), 12 rue des Professeurs Jeener et Brachet, B-6041 Gosselies, Belgium
* Author to whom correspondence should be addressed.
Received: 18 July 2013; in revised form: 21 October 2013 / Accepted: 28 October 2013 / Published: 8 November 2013
PDF Full-text Download PDF Full-Text [447 KB, uploaded 8 November 2013 11:58 CET]
Abstract: Ribonucleoprotein complexes are essential regulatory components in bacteria. In this review, we focus on the carbon storage regulator (Csr) network, which is well conserved in the bacterial world. This regulatory network is composed of the CsrA master regulator, its targets and regulators. CsrA binds to mRNA targets and regulates translation either negatively or positively. Binding to small non-coding RNAs controls activity of this protein. Expression of these regulators is tightly regulated at the level of transcription and stability by various global regulators (RNAses, two-component systems, alarmone). We discuss the implications of these complex regulations in bacterial adaptation.
Keywords: Csr network; Rsm network; global regulation; RNA-binding protein; sRNAs; post-transcriptional regulation

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Seyll, E.; Van Melderen, L. The Ribonucleoprotein Csr Network. Int. J. Mol. Sci. 2013, 14, 22117-22131.

AMA Style

Seyll E, Van Melderen L. The Ribonucleoprotein Csr Network. International Journal of Molecular Sciences. 2013; 14(11):22117-22131.

Chicago/Turabian Style

Seyll, Ethel; Van Melderen, Laurence. 2013. "The Ribonucleoprotein Csr Network." Int. J. Mol. Sci. 14, no. 11: 22117-22131.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert