Next Article in Journal
AlPOs Synthetic Factor Analysis Based on Maximum Weight and Minimum Redundancy Feature Selection
Next Article in Special Issue
New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein
Previous Article in Journal
SEPT12-Microtubule Complexes Are Required for Sperm Head and Tail Formation
Previous Article in Special Issue
RNA-Binding Proteins Impacting on Internal Initiation of Translation
Int. J. Mol. Sci. 2013, 14(11), 22117-22131; doi:10.3390/ijms141122117
Review

The Ribonucleoprotein Csr Network

 and
*
Received: 18 July 2013 / Revised: 21 October 2013 / Accepted: 28 October 2013 / Published: 8 November 2013
View Full-Text   |   Download PDF [447 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

Ribonucleoprotein complexes are essential regulatory components in bacteria. In this review, we focus on the carbon storage regulator (Csr) network, which is well conserved in the bacterial world. This regulatory network is composed of the CsrA master regulator, its targets and regulators. CsrA binds to mRNA targets and regulates translation either negatively or positively. Binding to small non-coding RNAs controls activity of this protein. Expression of these regulators is tightly regulated at the level of transcription and stability by various global regulators (RNAses, two-component systems, alarmone). We discuss the implications of these complex regulations in bacterial adaptation.
Keywords: Csr network; Rsm network; global regulation; RNA-binding protein; sRNAs; post-transcriptional regulation Csr network; Rsm network; global regulation; RNA-binding protein; sRNAs; post-transcriptional regulation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Seyll, E.; Van Melderen, L. The Ribonucleoprotein Csr Network. Int. J. Mol. Sci. 2013, 14, 22117-22131.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert