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The Ribonucleoprotein Csr Network
Laboratoire de Génétique et Physiologie Bactérienne, IBMM, Faculté des Sciences, Université Libre de Bruxelles (ULB), 12 rue des Professeurs Jeener et Brachet, B-6041 Gosselies, Belgium
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Received: 18 July 2013; in revised form: 21 October 2013 / Accepted: 28 October 2013 / Published: 8 November 2013
Abstract: Ribonucleoprotein complexes are essential regulatory components in bacteria. In this review, we focus on the carbon storage regulator (Csr) network, which is well conserved in the bacterial world. This regulatory network is composed of the CsrA master regulator, its targets and regulators. CsrA binds to mRNA targets and regulates translation either negatively or positively. Binding to small non-coding RNAs controls activity of this protein. Expression of these regulators is tightly regulated at the level of transcription and stability by various global regulators (RNAses, two-component systems, alarmone). We discuss the implications of these complex regulations in bacterial adaptation.
Keywords: Csr network; Rsm network; global regulation; RNA-binding protein; sRNAs; post-transcriptional regulation
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MDPI and ACS Style
Seyll, E.; Van Melderen, L. The Ribonucleoprotein Csr Network. Int. J. Mol. Sci. 2013, 14, 22117-22131.
Seyll E, Van Melderen L. The Ribonucleoprotein Csr Network. International Journal of Molecular Sciences. 2013; 14(11):22117-22131.
Seyll, Ethel; Van Melderen, Laurence. 2013. "The Ribonucleoprotein Csr Network." Int. J. Mol. Sci. 14, no. 11: 22117-22131.