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Int. J. Mol. Sci. 2013, 14(11), 22678-22696; doi:10.3390/ijms141122678

Membrane Signaling Induced by High Doses of Ionizing Radiation in the Endothelial Compartment. Relevance in Radiation Toxicity

CRCNA-UMR Inserm U892-CNRS 6299-Institut de Recherche en Santé de l'Université de Nantes, Nantes 44007, France
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Received: 9 October 2013 / Revised: 1 November 2013 / Accepted: 6 November 2013 / Published: 18 November 2013
(This article belongs to the collection Radiation Toxicity in Cells)
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Abstract

Tumor areas can now be very precisely delimited thanks to technical progress in imaging and ballistics. This has also led to the development of novel radiotherapy protocols, delivering higher doses of ionizing radiation directly to cancer cells. Despite this, radiation toxicity in healthy tissue remains a major issue, particularly with dose-escalation in these new protocols. Acute and late tissue damage following irradiation have both been linked to the endothelium irrigating normal tissues. The molecular mechanisms involved in the endothelial response to high doses of radiation are associated with signaling from the plasma membrane, mainly via the acid sphingomyelinase/ceramide pathway. This review describes this signaling pathway and discusses the relevance of targeting endothelial signaling to protect healthy tissues from the deleterious effects of high doses of radiation.
Keywords: radiotherapy; radiation toxicity; endothelium; plasma membrane; acid sphingomyelinase; ceramide radiotherapy; radiation toxicity; endothelium; plasma membrane; acid sphingomyelinase; ceramide
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Corre, I.; Guillonneau, M.; Paris, F. Membrane Signaling Induced by High Doses of Ionizing Radiation in the Endothelial Compartment. Relevance in Radiation Toxicity. Int. J. Mol. Sci. 2013, 14, 22678-22696.

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