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Int. J. Mol. Sci. 2013, 14(11), 21790-21804; doi:10.3390/ijms141121790

Combination of Fenretinide and Selenite Inhibits Proliferation and Induces Apoptosis in Ovarian Cancer Cells

Department of Obstetrics and Gynecology, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China
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Received: 20 July 2013 / Revised: 17 October 2013 / Accepted: 22 October 2013 / Published: 4 November 2013
(This article belongs to the Special Issue Genes and Pathways in the Pathogenesis of Ovarian Cancer)
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Abstract

The combination of fenretinide and selenite on ovarian cancer cells was investigated to assess its effects on proliferation and ability to induce apoptosis. Our results showed that fenretinide and selenite in combination significantly suppress the proliferation of ovarian cancer cells and induced apoptosis (including reactive oxygen species generation, and the loss of mitochondrial membrane potential) compared with either drug used alone. The caspase3/9-dependent pathway was triggered significantly in combination treatment, and moreover, the AMPK pathway also mediated the apoptosis induction in fenretinide and selenite combination. Fenretinide and selenite combination treatment was demonstrated to suppress tumor growth in vivo, this drug combination has been thus found to have an enhanced anti-tumor effect on ovarian cancers cells. View Full-Text
Keywords: ovarian cancers cell; fenretinide; selenite; combination; anti-tumor effect ovarian cancers cell; fenretinide; selenite; combination; anti-tumor effect
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Liu, J.; Li, J.; Zhang, J.-F.; Xin, X.-Y. Combination of Fenretinide and Selenite Inhibits Proliferation and Induces Apoptosis in Ovarian Cancer Cells. Int. J. Mol. Sci. 2013, 14, 21790-21804.

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