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Int. J. Mol. Sci. 2013, 14(11), 21805-21818; doi:10.3390/ijms141121805
Article

New Potential Antitumor Pyrazole Derivatives: Synthesis and Cytotoxic Evaluation

1,* , 2
 and 1
Received: 5 September 2013; in revised form: 22 October 2013 / Accepted: 28 October 2013 / Published: 4 November 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: New pyrazole derivatives were designed and synthesized as potential protein kinase inhibitors in the view to develop specific antitumor therapies. The structures of the compounds were elucidated using spectral and elemental analyses. The antitumor potential was estimated using wheat seeds and the general toxicity was evaluated by alternative methods, using invertebrate animals. One 3-aminopyrazole derivative emerged as a potential candidate for the development of future cytotoxic compounds.
Keywords: Artemia salina; Daphnia magna; Triticum aestivum; pyrazolyl thiourea Artemia salina; Daphnia magna; Triticum aestivum; pyrazolyl thiourea
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nitulescu, G.M.; Draghici, C.; Olaru, O.T. New Potential Antitumor Pyrazole Derivatives: Synthesis and Cytotoxic Evaluation. Int. J. Mol. Sci. 2013, 14, 21805-21818.

AMA Style

Nitulescu GM, Draghici C, Olaru OT. New Potential Antitumor Pyrazole Derivatives: Synthesis and Cytotoxic Evaluation. International Journal of Molecular Sciences. 2013; 14(11):21805-21818.

Chicago/Turabian Style

Nitulescu, George M.; Draghici, Constantin; Olaru, Octavian T. 2013. "New Potential Antitumor Pyrazole Derivatives: Synthesis and Cytotoxic Evaluation." Int. J. Mol. Sci. 14, no. 11: 21805-21818.


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