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Int. J. Mol. Sci. 2013, 14(10), 19782-19791; doi:10.3390/ijms141019782
Article

Relationship between Serum Osteocalcin Levels and Non-Alcoholic Fatty Liver Disease in Adult Males, South China

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Received: 31 July 2013; in revised form: 20 September 2013 / Accepted: 22 September 2013 / Published: 30 September 2013
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research)
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Abstract: AIM: To determine serum osteocalcin levels in South Chinese males with non-alcoholic fatty liver disease (NAFLD) and to examine the relation between serum osteocalcin and NAFLD. METHODS: Data were collected from 1683 men attending the Fangchenggang Area Male Healthy and Examination Survey (FAMHES) from September 2009 to December 2009. Serum osteocalcin was measured with electrochemiluminescence immunoassay. An abdominal ultrasonographic examination for all individuals was performed by two experienced ultrasonographers. The associations of serum osteocalcin with NAFLD were evaluated. RESULTS: The levels of serum osteocalcin were lower in 364 NAFLD participants than in 1319 non-NAFLD participants (24.51 ± 1.38 ng/mL vs. 20.81 ± 1.33 ng/mL, p < 0.001). Serum osteocalin level was associated with the scale of NAFLD (r = −0.150, p < 0.01). Serum osteocalin level tended to decrease with the scale of NAFLD. Binary logistic regression analysis showed that decreased ORs for NAFLD were observed from the first to the fourth osteocalcin quartiles. CONCLUSIONS: Our findings suggest that a lower serum osteocalcin level is associated with the presence of NAFLD.
Keywords: osteocalin; Insulin resistance; non-alcoholic fatty liver disease; ultrasonography osteocalin; Insulin resistance; non-alcoholic fatty liver disease; ultrasonography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Liu, J.-J.; Chen, Y.-Y.; Mo, Z.-N.; Tian, G.-X.; Tan, A.-H.; Gao, Y.; Yang, X.-B.; Zhang, H.-Y.; Li, Z.-X. Relationship between Serum Osteocalcin Levels and Non-Alcoholic Fatty Liver Disease in Adult Males, South China. Int. J. Mol. Sci. 2013, 14, 19782-19791.

AMA Style

Liu J-J, Chen Y-Y, Mo Z-N, Tian G-X, Tan A-H, Gao Y, Yang X-B, Zhang H-Y, Li Z-X. Relationship between Serum Osteocalcin Levels and Non-Alcoholic Fatty Liver Disease in Adult Males, South China. International Journal of Molecular Sciences. 2013; 14(10):19782-19791.

Chicago/Turabian Style

Liu, Jun-Jie; Chen, Yuan-Yuan; Mo, Zeng-Nan; Tian, Gui-Xiang; Tan, Ai-Hua; Gao, Yong; Yang, Xiao-Bo; Zhang, Hai-Ying; Li, Zhi-Xian. 2013. "Relationship between Serum Osteocalcin Levels and Non-Alcoholic Fatty Liver Disease in Adult Males, South China." Int. J. Mol. Sci. 14, no. 10: 19782-19791.



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