Int. J. Mol. Sci. 2013, 14(10), 19416-19433; doi:10.3390/ijms141019416

Mechanisms of Chemical Carcinogenesis in the Kidneys

1,2email, 1,2email, 1,2email, 1,2email and 1,2,* email
Received: 2 May 2013; in revised form: 5 September 2013 / Accepted: 9 September 2013 / Published: 25 September 2013
(This article belongs to the Special Issue Molecular Mechanisms of Organ-Specific Toxicity)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Chemical carcinogens are substances which induce malignant tumours, increase their incidence or decrease the time taken for tumour formation. Often, exposure to chemical carcinogens results in tissue specific patterns of tumorigenicity. The very same anatomical, biochemical and physiological specialisations which permit the kidney to perform its vital roles in maintaining tissue homeostasis may in fact increase the risk of carcinogen exposure and contribute to the organ specific carcinogenicity observed with numerous kidney carcinogens. This review will address the numerous mechanisms which play a role in the concentration, bioactivation, and uptake of substances from both the urine and blood which significantly increase the risk of cancer in the kidney.
Keywords: carcinogen; kidney; proximal tubule; mechanism; bioactivation
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MDPI and ACS Style

Radford, R.; Frain, H.; Ryan, M.P.; Slattery, C.; McMorrow, T. Mechanisms of Chemical Carcinogenesis in the Kidneys. Int. J. Mol. Sci. 2013, 14, 19416-19433.

AMA Style

Radford R, Frain H, Ryan MP, Slattery C, McMorrow T. Mechanisms of Chemical Carcinogenesis in the Kidneys. International Journal of Molecular Sciences. 2013; 14(10):19416-19433.

Chicago/Turabian Style

Radford, Robert; Frain, Helena; Ryan, Michael P.; Slattery, Craig; McMorrow, Tara. 2013. "Mechanisms of Chemical Carcinogenesis in the Kidneys." Int. J. Mol. Sci. 14, no. 10: 19416-19433.

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