Next Article in Journal
Systematic Exploration of Natural and Synthetic Flavonoids for the Inhibition of Staphylococcus aureus Biofilms
Previous Article in Journal
Inhibition of Oxidative Stress by Low-Molecular-Weight Polysaccharides with Various Functional Groups in Skin Fibroblasts
Previous Article in Special Issue
Detection of Ricin Intoxication in Mice Using Serum Peptide Profiling by MALDI-TOF/MS
Int. J. Mol. Sci. 2013, 14(10), 19416-19433; doi:10.3390/ijms141019416

Mechanisms of Chemical Carcinogenesis in the Kidneys

, 1,2
, 1,2
, 1,2
 and 1,2,*
Received: 2 May 2013 / Revised: 5 September 2013 / Accepted: 9 September 2013 / Published: 25 September 2013
(This article belongs to the Special Issue Molecular Mechanisms of Organ-Specific Toxicity)
View Full-Text   |   Download PDF [465 KB, uploaded 19 June 2014]   |   Browse Figures
Abstract: Chemical carcinogens are substances which induce malignant tumours, increase their incidence or decrease the time taken for tumour formation. Often, exposure to chemical carcinogens results in tissue specific patterns of tumorigenicity. The very same anatomical, biochemical and physiological specialisations which permit the kidney to perform its vital roles in maintaining tissue homeostasis may in fact increase the risk of carcinogen exposure and contribute to the organ specific carcinogenicity observed with numerous kidney carcinogens. This review will address the numerous mechanisms which play a role in the concentration, bioactivation, and uptake of substances from both the urine and blood which significantly increase the risk of cancer in the kidney.
Keywords: carcinogen; kidney; proximal tubule; mechanism; bioactivation carcinogen; kidney; proximal tubule; mechanism; bioactivation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |

MDPI and ACS Style

Radford, R.; Frain, H.; Ryan, M.P.; Slattery, C.; McMorrow, T. Mechanisms of Chemical Carcinogenesis in the Kidneys. Int. J. Mol. Sci. 2013, 14, 19416-19433.

AMA Style

Radford R, Frain H, Ryan MP, Slattery C, McMorrow T. Mechanisms of Chemical Carcinogenesis in the Kidneys. International Journal of Molecular Sciences. 2013; 14(10):19416-19433.

Chicago/Turabian Style

Radford, Robert; Frain, Helena; Ryan, Michael P.; Slattery, Craig; McMorrow, Tara. 2013. "Mechanisms of Chemical Carcinogenesis in the Kidneys." Int. J. Mol. Sci. 14, no. 10: 19416-19433.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert