- freely available
Mechanisms of Chemical Carcinogenesis in the Kidneys
AbstractChemical carcinogens are substances which induce malignant tumours, increase their incidence or decrease the time taken for tumour formation. Often, exposure to chemical carcinogens results in tissue specific patterns of tumorigenicity. The very same anatomical, biochemical and physiological specialisations which permit the kidney to perform its vital roles in maintaining tissue homeostasis may in fact increase the risk of carcinogen exposure and contribute to the organ specific carcinogenicity observed with numerous kidney carcinogens. This review will address the numerous mechanisms which play a role in the concentration, bioactivation, and uptake of substances from both the urine and blood which significantly increase the risk of cancer in the kidney.
Share & Cite This Article
Radford, R.; Frain, H.; Ryan, M.P.; Slattery, C.; McMorrow, T. Mechanisms of Chemical Carcinogenesis in the Kidneys. Int. J. Mol. Sci. 2013, 14, 19416-19433.View more citation formats
Radford R, Frain H, Ryan MP, Slattery C, McMorrow T. Mechanisms of Chemical Carcinogenesis in the Kidneys. International Journal of Molecular Sciences. 2013; 14(10):19416-19433.Chicago/Turabian Style
Radford, Robert; Frain, Helena; Ryan, Michael P.; Slattery, Craig; McMorrow, Tara. 2013. "Mechanisms of Chemical Carcinogenesis in the Kidneys." Int. J. Mol. Sci. 14, no. 10: 19416-19433.